Serum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseases

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dc.contributor.authorCakir, Mehtap
dc.contributor.authorLevendoglu, Funda
dc.contributor.authorKiyici, Aysel
dc.contributor.authorCoskun, Yasemin
dc.date.accessioned2020-03-26T18:16:07Z
dc.date.available2020-03-26T18:16:07Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. Design: A total of 80 patients were recruited to the study, which included treatment-naive hypothyroid Hashimoto's thyroiditis (n == 19) and hyperthyroid Graves' disease (GD; n == 21), euthyroid thyroid autoantibody-positive (n == 20) and -negative (n == 20) patients. Methods: All patients underwent a thorough sensorimotor and neuromuscular examination. Serum samples were kept in -- 20 degrees A degrees C for further CXCL10 measurements with ELISA. Results: There was a significant difference with regard to serum CXCL10 levels only between GD and euthyroid thyroid autoantibody-negative patient groups [187(12-418) vs. 37.5(2-542) pg/ml, p < 0.05]. However, a comparison of newly diagnosed AITD patients with and without neuromuscular manifestations in terms of serum CXCL10 levels yielded no significant difference. When a correlation of existence of a neuromuscular manifestation and serum CXCL10 levels was evaluated, a significantly positive correlation was noted between carpal tunnel syndrome (CTS) and serum CXCL10 levels [207 (95-748) pg/ml in CTS-positive vs. 117 (2-977) pg/ml in CTS-negative patients, p < 0.05]. Conclusions: In this study, from a number of neuromuscular manifestations, only the existence of CTS correlated with significantly higher CXCL10 levels in the whole study group. Further studies with larger numbers of patients with autoimmune-based hyper- and hypothyroidism may better clarify the hypothesis regarding a relationship between serum CXCL10 levels and neuromuscular manifestations of AITD.en_US
dc.identifier.doi10.3109/08916934.2011.561818en_US
dc.identifier.endpage503en_US
dc.identifier.issn0891-6934en_US
dc.identifier.issn1607-842Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid21457060en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://dx.doi.org/10.3109/08916934.2011.561818
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26813
dc.identifier.volume44en_US
dc.identifier.wosWOS:000293391900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofAUTOIMMUNITYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGraves' diseaseen_US
dc.subjectHashimoto's thyroiditisen_US
dc.subjectautoimmunityen_US
dc.subjectchemokineen_US
dc.subjectneuromuscularen_US
dc.titleSerum CXCL10 levels and neuromuscular manifestations in patients with autoimmune thyroid diseasesen_US
dc.typeArticleen_US

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