Hyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: Protective role of melatonin

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dc.contributor.authorMogulkoc, R
dc.contributor.authorBaltaci, AK
dc.contributor.authorOztekin, E
dc.contributor.authorAydin, L
dc.contributor.authorTuncer, I
dc.date.accessioned2020-03-26T16:57:19Z
dc.date.available2020-03-26T16:57:19Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: The present study aimed at determining how 3-weeks intraperitoneal melatonin administration affected oxidative stress caused by experimental hyperthyroidism. MATERIALS AND METHODS: The study was conducted on 30 male rats of Spraque-Dawley species. The experimental animals were divided to 3 groups (control, hyperthyroidism and hyperthyroidism+melatonin). The supplementation was continued for 3 weeks after which the animals were sacrified and tissue malondyaldehyde (MDA) and glutathione (GSH) levels were determined. RESULTS: MDA levels in kidney and testis tissues in hyperthyroidism group were higher than those in control and hyperthyroidism+melatonin administered groups (p < 0.001) and levels in hyperthyroidism + melatonin administered group were higher than those in the control group (p < 0.001). The highest GSH levels were obtained in hyperthyroidism + melatonin-administered group (p < 0.001) and GSH levels in hyperthyroidism group were higher than those in the control group (p < 0.001). CONCLUSION: Results of the study demonstrate that hyperthyroidism induced by 3-weeks L-thyroxine administration increased oxidative stress in kidney and testis tissues and that although melatonin administration inhibited this stress to a certain extent, it could not bring the stress down to the level in controls.en_US
dc.identifier.endpage810en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid16380687en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage806en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19762
dc.identifier.volume26en_US
dc.identifier.wosWOS:000236048900036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMAGHIRA & MAAS PUBLICATIONSen_US
dc.relation.ispartofNEUROENDOCRINOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthyperthyroidismen_US
dc.subjectmelatonin administrationen_US
dc.subjectoxidant stressen_US
dc.subjectkidneyen_US
dc.subjecttestisen_US
dc.titleHyperthyroidism causes lipid peroxidation in kidney and testis tissues of rats: Protective role of melatoninen_US
dc.typeArticleen_US

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