The effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edema

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dc.contributor.authorBayir, Ayseguel
dc.contributor.authorKiresi, Demet Aydogdu
dc.contributor.authorKara, Hasan
dc.contributor.authorCengiz, Sahika Liva
dc.contributor.authorKocak, Sedat
dc.contributor.authorOezdinc, Serife
dc.contributor.authorAk, Ahmet
dc.date.accessioned2020-03-26T17:28:07Z
dc.date.available2020-03-26T17:28:07Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to compare the effects of mannitol and melatonin on brain edema secondary to trauma using magnetic resonance imaging (MRI). Methods : A mild traumatic brain injury with the Feeney method was performed upon twelve New Zealand rabbits. Three hours after the trauma was inflicted, MRI images were obtained, then the subjects were divided into two groups : a mannitol group and a melatonin group. The mannitol group (n = 6) was given 2 gr/kg of 20% mannitol IV over 10 minutes and the melatonin group (n = 6) received 100 mg/kg of melatonin IV over 30 minutes. Thirty-three hours after the first MRI, MRI was repeated. The 3-hour and 36-hour post-trauma MRI images in both groups were scored regarding signs of edema and extent of brain tissue protrusion in a blinded fashion by a staff radiologist. Intragroup and intergroup comparisons were made using the Fisher exact test and chi square test. Comparison of brain tissue protrusion measurements was done using the Mann Whitney U test. Results : Signs of raised intraventricular pressure, contusion and parenchymal edema were more prevelant, and parenchymal protrusion was more prominent on the 36-hour MRI in both mannitol and melatonin groups. No significant difference was,found between the melatonin and mannitol groups in any parameter in the MRI images performed 3 and 36 hours after the head trauma. Conclusions : In this animal model, melatonin and mannitol had similar effects on brain edema, as demonstrated on MRI 3 and 36 hours after head trauma.en_US
dc.identifier.endpage154en_US
dc.identifier.issn0300-9009en_US
dc.identifier.issn2240-2993en_US
dc.identifier.issue4en_US
dc.identifier.pmid19239045en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22716
dc.identifier.volume108en_US
dc.identifier.wosWOS:000263358900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofACTA NEUROLOGICA BELGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHead traumaen_US
dc.subjectsecondary brain damageen_US
dc.subjectbrain edemaen_US
dc.subjectMRIen_US
dc.subjectmelatoninen_US
dc.subjectmannitolen_US
dc.titleThe effects of mannitol and melatonin on MRI findings in an animal model of traumatic brain edemaen_US
dc.typeArticleen_US

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