Effects of platelet rich plasma on colonic anastomosis

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dc.contributor.authorYol, Serdar
dc.contributor.authorTekin, Ahmet
dc.contributor.authorYilmaz, Hueseyin
dc.contributor.authorKuecuekkartallar, Tevfik
dc.contributor.authorEsen, Hasan
dc.contributor.authorCaglayan, Osman
dc.contributor.authorTatkan, Yueksel
dc.date.accessioned2020-03-26T17:26:46Z
dc.date.available2020-03-26T17:26:46Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose. To investigate the effect of platelet-rich plasma (PRP) on tissue maturation and wound healing in experimental colonic anastomosis. Materials and methods. Thirty Sprague Dawley rats were divided into three groups of 10 rats each. Group I (control group) was subjected to colon anastomosis only. Group II (PRP group) was subjected to colon anastomosis and topical PRP was applied. Group III (Bioglue group) was subjected to colon anastomosis and topical tissue sealant was applied (Bioglue; Cryo-life, Kennesaw, GA). The rats were sacrificed on postoperative day 7, and the bursting pressure of the anastomosis and tissue hydroxyproline levels were measured; histopathological changes on the anastomosis line were also examined. Results. The bursting pressure was statistically higher in the PRP group than in the control and Bioglue groups (P < 0.05). The hydroxyproline levels were also statistically higher in the PRP group than in the control and Bioglue groups (P < 0.05). Histopathologically, there was less inflammatory cell infiltration, intensive fibroblast development, and rich collagen production in the PRP group. Conclusion. PRP may be used in colon anastomosis, especially in patients with impaired wound healing, to obtain a better anastomotic strength. (c) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2007.05.015en_US
dc.identifier.endpage194en_US
dc.identifier.issn0022-4804en_US
dc.identifier.issue2en_US
dc.identifier.pmid18028949en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage190en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jss.2007.05.015
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22361
dc.identifier.volume146en_US
dc.identifier.wosWOS:000255410000006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectplatelet-rich plasmaen_US
dc.subjectcolonic anastomosisen_US
dc.subjectanastomotic failureen_US
dc.subjectBioglueen_US
dc.titleEffects of platelet rich plasma on colonic anastomosisen_US
dc.typeArticleen_US

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