The cerebroprotective effects of pentoxifylline and aprotinin during cardiopulmonary bypass in dogs

Basit Öğe Kaydı
dc.contributor.authorDurgut, K
dc.contributor.authorHosgor, K
dc.contributor.authorGormus, N
dc.contributor.authorOzergin, U
dc.contributor.authorSolak, H
dc.date.accessioned2020-03-26T16:55:31Z
dc.date.available2020-03-26T16:55:31Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.descriptionWorkshop on Therapeutic Filtration and Extracorporeal Circulation -- 38177 -- Hammersmith Hosp, London, ENGLANDen_US
dc.description.abstractObjective: The purpose of this study was to investigate the cerebroprotective effects of pentoxifylline (PNX) and aprotinin in dogs using cardiopulmonary bypass (CPB). Materials and methods: Eighteen clinically healthy dogs were divided into three groups: Group 1 ( control, n = 6), Group 2 (PNX, n = 6), and Group 3 (aprotinin, n = 6). PNX was administered at a dose of 300 mg/day in Group 2 three days before the operation and during the operation. Half a million IU aprotinin were added to the prime solution and 500 000 IU were transfused via a central venous jugular catheter preoperatively in Group 3. Blood samples were taken from the central jugular vein before and after CPB and interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and S100beta protein were measured. Gliosis was investigated histopathologically in cerebral cortex biopsy samples under light microscopy. Results: The preoperative results of IL-6, TNF-alpha, and S100beta protein values were found to be significantly higher (p < 0.001) when compared with postoperative values. This significant difference was observed in the same parameters between Groups 1 and 2, and 1 and 3 (p < 0.001). There was no significant difference between Groups 2 and 3. Comparison between pre- and postoperative levels of IL-6 and TNF-alpha for Group 2 and Group 3 revealed statistically significant differences (p < 0.001), whereas S100&beta; protein levels did not. Histopathological examinations showed significant differences between the control group and PNX and aprotinin, and between aprotinin and PNX groups (p < 0.001). Conclusion: PNX and aprotinin might be useful in order to reduce postoperative cerebral damage in patients undergoing cardiac surgery with CPB.en_US
dc.identifier.doi10.1191/0267659104pf724oaen_US
dc.identifier.endpage106en_US
dc.identifier.issn0267-6591en_US
dc.identifier.issue2en_US
dc.identifier.pmid15162924en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://dx.doi.org/10.1191/0267659104pf724oa
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19226
dc.identifier.volume19en_US
dc.identifier.wosWOS:000221462200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherARNOLD, HODDER HEADLINE PLCen_US
dc.relation.ispartofPERFUSION-UKen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe cerebroprotective effects of pentoxifylline and aprotinin during cardiopulmonary bypass in dogsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
durgut2004.pdf
Boyut:
654.46 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu