Nicotinamide N-Methyltransferase expression in high-grade serous carcinoma and its association with survival
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER INDIA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction Ovarian cancer is the most lethal gynecological malignancy. Mechanisms involved in the progression of primary high-grade serous carcinoma (HGSC) into metastatic carcinoma are not understood. Nicotinamide N-methyltransferase (NNMT) is overexpressed in cancer, and its overexpression leads to epigenetic changes through hypomethylation of histones. It plays a role in epithelial-mesenchymal transition and sustenance of cancer stem cells. NNMT expression in primary and metastases of ovarian carcinoma and its relationship with survival have not been studied before. Materials and Methods We compared the expression of NNMT between primary and matched synchronous metastatic carcinoma of patients, diagnosed with HGSC. Benign ovarian and omental tissues were used as controls. The relationships between NNMT expression and relapse-free and disease-specific survival were analyzed. Results NNMT expression in metastases was significantly higher than matched primary carcinoma. NNMT was overexpressed in the stroma of primary and metastatic tumors. Increased NNMT expression was associated with decreased relapse-free and disease-specific survival. Conclusion This study detected a higher expression of NNMT in metastases of HGSC compared to matched primary and associated increased metastatic NNMT expression with decreased survival. Upregulation of NNMT in tumor stroma suggests it plays a role in desmoplasia. Targeting of NNMT and desmoplasia may play a critical role in the treatment of HGSC.
Açıklama
Anahtar Kelimeler
Nicotinamide N-methyltransferase, High-grade serous carcinoma, p53, Disease-specific survival, Relapse-free survival
Kaynak
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
17
Sayı
4
Künye
Akar, S., Harmankaya, İ., Uğraş, S., Çelik, Ç. (2019). Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival. Indian Journal of Gynecologic Oncology, 17(4), 82.
