Nicotinamide N-Methyltransferase expression in high-grade serous carcinoma and its association with survival

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dc.authorid0000-0002-0466-140X
dc.authorid0000-0003-2796-1250
dc.authorid0000-0003-0108-697X
dc.authorid0000-0001-6165-5092
dc.contributor.authorAkar, Serra.
dc.contributor.authorHarmankaya, İsmail.
dc.contributor.authorUğraş, Serdar.
dc.contributor.authorÇelik, Çetin.
dc.date.accessioned2020-03-26T20:15:29Z
dc.date.available2020-03-26T20:15:29Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction Ovarian cancer is the most lethal gynecological malignancy. Mechanisms involved in the progression of primary high-grade serous carcinoma (HGSC) into metastatic carcinoma are not understood. Nicotinamide N-methyltransferase (NNMT) is overexpressed in cancer, and its overexpression leads to epigenetic changes through hypomethylation of histones. It plays a role in epithelial-mesenchymal transition and sustenance of cancer stem cells. NNMT expression in primary and metastases of ovarian carcinoma and its relationship with survival have not been studied before. Materials and Methods We compared the expression of NNMT between primary and matched synchronous metastatic carcinoma of patients, diagnosed with HGSC. Benign ovarian and omental tissues were used as controls. The relationships between NNMT expression and relapse-free and disease-specific survival were analyzed. Results NNMT expression in metastases was significantly higher than matched primary carcinoma. NNMT was overexpressed in the stroma of primary and metastatic tumors. Increased NNMT expression was associated with decreased relapse-free and disease-specific survival. Conclusion This study detected a higher expression of NNMT in metastases of HGSC compared to matched primary and associated increased metastatic NNMT expression with decreased survival. Upregulation of NNMT in tumor stroma suggests it plays a role in desmoplasia. Targeting of NNMT and desmoplasia may play a critical role in the treatment of HGSC.en_US
dc.description.sponsorship[18401135]en_US
dc.description.sponsorshipThe study was funded by Scientific Research endorsement (#18401135).en_US
dc.identifier.citationAkar, S., Harmankaya, İ., Uğraş, S., Çelik, Ç. (2019). Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival. Indian Journal of Gynecologic Oncology, 17(4), 82.
dc.identifier.doi10.1007/s40944-019-0327-9en_US
dc.identifier.issn2363-8397en_US
dc.identifier.issn2363-8400en_US
dc.identifier.issue4en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s40944-019-0327-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38039
dc.identifier.volume17en_US
dc.identifier.wosWOS:000486513700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAkar, Serra.
dc.institutionauthorHarmankaya, İsmail.
dc.institutionauthorUğraş, Serdar.
dc.institutionauthorÇelik, Çetin.
dc.language.isoenen_US
dc.publisherSPRINGER INDIAen_US
dc.relation.ispartofINDIAN JOURNAL OF GYNECOLOGIC ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNicotinamide N-methyltransferaseen_US
dc.subjectHigh-grade serous carcinomaen_US
dc.subjectp53en_US
dc.subjectDisease-specific survivalen_US
dc.subjectRelapse-free survivalen_US
dc.titleNicotinamide N-Methyltransferase expression in high-grade serous carcinoma and its association with survivalen_US
dc.typeArticleen_US

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