Clinical and immunological effects of Newcastle disease virus vaccine on bovine papillomatosis

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dc.contributor.authorAvki, S
dc.contributor.authorTurutoglu, H
dc.contributor.authorSimsek, A
dc.contributor.authorUnsal, A
dc.date.accessioned2020-03-26T16:48:00Z
dc.date.available2020-03-26T16:48:00Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractNewcastle disease virus (NDV) has antineoplastic and immunostimulatory properties, and it is currently being clinically tested in anticancer therapy. In order to analyze the immunostimulatory effects of NDV on bovine papillomatosis, we inoculated 14 cows subcutaneously with an attenuated vaccine containing the LaSota strain of NDV (LS-NDV). Four cows with papillomatosis served as controls. Serum samples were collected from each animal 1 h before and, 7 and 21 days after inoculation. In inoculated cows, on days 7 and 21 the mean antibody titers were log(2) 2.43 +/- 0.92 and log(2) 5.57 +/- 0.72 by haemagglutination inhibition (HI), and the mean levels of tumor necrosis factor-alpha (TNF-alpha) were 5.80 +/- 4.19 and 5.39 +/- 12.66 ng/ml by WEHI-164 cytotoxicity assay. Significant differences between inoculated and control animals were evident for antibody titers on day 21 and clinical scores on day 60. A correlation was evident between the TNF-alpha activities and clinical scores on day 21. The clinical observations at day 60 showed that the papillomas in five cows were completely resolved (36%), one animal had no alterations on clinical appearance of the tumor (7%), and papillomas in eight cows were regressed (57%). In conclusion, these results demonstrated that inoculation of LS-NDV vaccine stimulates an antibody response and limited increase in TNF-alpha activity and may enhance clinical recovery in bovine papillomatosis. (C) 2003 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.vetimm.2003.10.003en_US
dc.identifier.endpage16en_US
dc.identifier.issn0165-2427en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.pmid15127837en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.vetimm.2003.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18969
dc.identifier.volume98en_US
dc.identifier.wosWOS:000189039500002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofVETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectnon-specific immunostimulationen_US
dc.subjectbovine papillomatosisen_US
dc.subjectNewcastle disease virusen_US
dc.subjectTNF-alphaen_US
dc.titleClinical and immunological effects of Newcastle disease virus vaccine on bovine papillomatosisen_US
dc.typeArticleen_US

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