Pyridoxine may protect the cerebellar granular cells against glutamate-induced toxicity

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dc.contributor.authorBueyuekokuroglu, Mehmet Emin
dc.contributor.authorGepdiremen, Akcahan
dc.contributor.authorTastekin, Ayhan
dc.contributor.authorOrs, Rahmi
dc.date.accessioned2020-03-26T17:18:00Z
dc.date.available2020-03-26T17:18:00Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the possible protective effect of the pyridoxine against glutamate-induced neurotoxicity in cerebellar granular cell culture of rat pups is investigated for its therapeutic potential. Glutamate (10(-7) M) was administered to cerebellar granular cell cultures that were prepared from one-day-old Sprague-Dawley rats. The neuroprotective effect of pyridoxine was examined. Pyridoxine at the doses of 10(-8), 10(-7), 10(-6), and 10(-5) M was introduced into the culture flasks before inclusion of glutamate. Pyridoxine at the doses of 10(-8) M and 10(-7) M significantly reduced glutamate cytotoxicity. A 10(-7) M dose of pyridoxine proved to be more effective than a 10(-8) M dose. The present study demonstrates that pyridoxine may protect glutamate-induced neurotoxicity. Neuroprotective effect of pyridoxine, at least in part, may result from its anti-glutamatergic activity. Pyridoxine merits further investigation as a therapeutic option in hypoxic-ischemic brain injury.en_US
dc.identifier.doi10.1024/0300-9831.77.5.336en_US
dc.identifier.endpage340en_US
dc.identifier.issn0300-9831en_US
dc.identifier.issn1664-2821en_US
dc.identifier.issue5en_US
dc.identifier.pmid18453318en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage336en_US
dc.identifier.urihttps://dx.doi.org/10.1024/0300-9831.77.5.336
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21558
dc.identifier.volume77en_US
dc.identifier.wosWOS:000253027200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVERLAG HANS HUBERen_US
dc.relation.ispartofINTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpyridoxineen_US
dc.subjectneuronen_US
dc.subjectcultureen_US
dc.subjectglutamateen_US
dc.subjectraten_US
dc.titlePyridoxine may protect the cerebellar granular cells against glutamate-induced toxicityen_US
dc.typeArticleen_US

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