Two Ganoderma species: profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorSarıkürkcü, Cengiz
dc.contributor.authorGüneş, Erdoğan
dc.contributor.authorUysal, Ahmet
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorUysal, Şengül
dc.contributor.authorGüngör, Halil
dc.date.accessioned2020-03-26T19:07:49Z
dc.date.available2020-03-26T19:07:49Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis work reports the antioxidant, antimicrobial, and inhibitory effects of methanol and water extracts from Ganoderma applanatum (GAM: methanol extract and GAW: water extract) and G. resinaceum (GRM: methanol extract and GRW: water extract) against cholinesterase, tyrosinase, alpha-amylase and alpha-glucosidase. The total phenolics, flavonoids contents, and HPLC profile of phenolic components present in the extracts, were also determined. Antioxidant activities were investigated by using different assays, including DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum and metal chelating assays. Antimicrobial activity of the tested Ganoderma extracts was also studied by the broth microdilution method. Generally, the highest antioxidant (59.24 mg TEs per g extract for DPPH, 41.32 mg TEs per g extract for ABTS, 41.35 mg TEs per g extract for CUPRAC, 49.68 mg TEs per g extract for FRAP, 130.57 mg AAEs per g extract for phosphomolybdenum and 26.92 mg EDTAEs per g extract) and enzyme inhibitory effects (1.47 mg GALAEs per g extract for AChE, 1.51 mg GALAEs per g extract for BChE, 13.40 mg KAEs per g extract for tyrosinase, 1.13 mmol ACEs per g extract for alpha-amylase and 2.20 mmol ACEs per g extract for alpha-glucosidase) were observed in GRM, which had the highest concentrations of phenolics (37.32 mg GAEs g(-1) extract). Again, Ganoderma extracts possess weak antibacterial and antifungal activities. Apigenin and protocatechuic acid were determined as the main components in GRM (1761 mu g per g extract) and GAM (165 mu g per g extract), respectively. The results suggest that the Ganoderma species may be considered as a candidate for preparing new food supplements and can represent a good model for the development of new drug formulations.en_US
dc.identifier.doi10.1039/c5fo00665aen_US
dc.identifier.endpage2802en_US
dc.identifier.issn2042-6496en_US
dc.identifier.issn2042-650Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid26165701en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2794en_US
dc.identifier.urihttps://dx.doi.org/10.1039/c5fo00665a
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32717
dc.identifier.volume6en_US
dc.identifier.wosWOS:000359128700039en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherROYAL SOC CHEMISTRYen_US
dc.relation.ispartofFOOD & FUNCTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleTwo Ganoderma species: profiling of phenolic compounds by HPLC-DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disordersen_US
dc.typeArticleen_US

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