Seasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis

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dc.contributor.authorDemirkok, Sevtap Sipahi
dc.contributor.authorBasaranoglu, Metin
dc.contributor.authorCoker, Elif
dc.contributor.authorKarayel, Tuncer
dc.date.accessioned2020-03-26T17:18:09Z
dc.date.available2020-03-26T17:18:09Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objectives: Sarcoidosis is a systemic granulomatous disease of unknown aetiology and pathogenesis. This study evaluated the seasonal variation in the onset of symptoms, Tuberculin anergy and Kveim positive reaction in a cohort of 492 patients with sarcoidosis and in a subgroup of 248 patients with known Kveim test responses. Methods: The medical records of 492 patients with sarcoidosis were retrospectively reviewed. Roger's test for cyclic variation was used to assess the statistical significance of the observed seasonal variation. Results: For all sarcoidosis patients (n = 492) the onset of symptoms was most frequent in spring (61.8%) and least frequent in summer (31.7%) (P < 0.001). For patients with Tuberculin anergy (n = 364) the onset of symptoms was most frequent in spring and least frequent in autumn (P < 0.001); there was no seasonal variation among Tuberculin positive patients (n = 128). Of those patients with a Kveim test result (n = 248), the onset of symptoms was most frequent in spring and least frequent in summer (P < 0.001); there was no seasonal variation for patients with a negative Kveim results (n = 50 patients). Conclusions: The onset of the symptoms was most frequent in spring and least frequent in the second half of the year (summer or autumn) in patients with sarcoidosis, Tuberculin anergy and a positive Kveim reaction. The significance of this finding in relation to aetiology and clinical utility needs to be further assessed.en_US
dc.identifier.doi10.1111/j.1440-1843.2007.01062.xen_US
dc.identifier.endpage593en_US
dc.identifier.issn1323-7799en_US
dc.identifier.issn1440-1843en_US
dc.identifier.issue4en_US
dc.identifier.pmid17587428en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage591en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1440-1843.2007.01062.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21597
dc.identifier.volume12en_US
dc.identifier.wosWOS:000247440300019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofRESPIROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectKveim reactionen_US
dc.subjectonset of symptomen_US
dc.subjectsarcoidosisen_US
dc.subjectseasonalityen_US
dc.subjectTuberculinen_US
dc.titleSeasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosisen_US
dc.typeArticleen_US

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