Gabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trial

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dc.contributor.authorBiyik, Zeynep
dc.contributor.authorSolak, Yalcin
dc.contributor.authorAtalay, Huseyin
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorGuney, Figen
dc.contributor.authorTurk, Suleyman
dc.date.accessioned2020-03-26T18:42:02Z
dc.date.available2020-03-26T18:42:02Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn dialysis patients, painful peripheral neuropathy (PPN) is associated with sleep disturbance and mood disorders. Our goal was to compare the effects of gabapentin and pregabalin on improving sleep quality and depression among hemodialysis patients with PPN. Fifty hemodialysis patients with PPN were randomized into 2 groups, to receive gabapentin and pregabalin, respectively. After 6 weeks of treatment, patients underwent a 2-week washout period, followed by crossover and another 6 weeks of treatment. All patients underwent electromyography (EMG) at the outset and completed the modified Short Form of McGill Pain Questionnaire (SF-MPQ), the Beck Depression Inventory (BDI) and the Pittsburgh Sleep Quality (PSQI) assessment at baseline and at the end of the study. Forty out of 50 patients completed the 14-week study period. Thirty-one out of 40 patients (77.5 %) had EMG-proven PPN. Both gabapentin and pregabalin significantly improved SF-MPQ, BDI and PSQI scores at the end of the study compared with pretreatment scores (p < 0.001). There was no significant difference between the two drugs in any studied parameter. Our results showed for the first time a good and similar efficacy of both drugs on pain intensity, quality of sleep and depression in hemodialysis patients with PPN.en_US
dc.identifier.doi10.1007/s11255-012-0193-1en_US
dc.identifier.endpage837en_US
dc.identifier.issn0301-1623en_US
dc.identifier.issn1573-2584en_US
dc.identifier.issue3en_US
dc.identifier.pmid22644743en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage831en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11255-012-0193-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29535
dc.identifier.volume45en_US
dc.identifier.wosWOS:000320843400036en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofINTERNATIONAL UROLOGY AND NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDepressionen_US
dc.subjectGabapentinen_US
dc.subjectHemodialysisen_US
dc.subjectPainful peripheral neuropathyen_US
dc.subjectPregabalinen_US
dc.subjectSleepen_US
dc.titleGabapentin versus pregabalin in improving sleep quality and depression in hemodialysis patients with peripheral neuropathy: a randomized prospective crossover trialen_US
dc.typeArticleen_US

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