Phenobarbital Effects on Brain and Liver Tissues Enzyme Activity in Balb/c Mice

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dc.contributor.authorYazar, Enver
dc.contributor.authorDemir, O.
dc.contributor.authorElmas, Muammer
dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorTraş, Bünyamin
dc.date.accessioned2020-03-26T16:39:26Z
dc.date.available2020-03-26T16:39:26Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of the present study was to investigate the effect of phenobarbital on some brain and liver tissue enzyme activities in Balb/C mice. Forty male Balb/C mice were used. Ten mice served as a control group, and thirty mice were administered with phenobarbital (80 mg(.)kg(-1) body mass, single oral dose). Brain and liver samples were taken at 6, 12 and 24 h after drug, administration. Brain and liver tissues alkaline phosphatase, aspartate aminotransferase, gamma glutamyl transferase and amylase activities were measured by autoanalyzer. Phenobarbital did not affect gamma glutamyl transferase and amylase activities in the brain and liver, and alkaline phosphatase and aspartate aminotransferase activities in the liver. However, statistically significant (p < 0.05) increases of alkaline phosphatase and aspartate aminotransferase activities were observed in the brain. In general, after phenobarbital administration, serum alkaline phosphatase and aspartate aminotransferase activities increase and these increases are believed to be derived from the liver. These result suggest that brain may contribute to increased activities of these enzymes in serum in Balb/C mice.en_US
dc.identifier.citationYazar, E., Demir, O., Elmas, M., Baş, A. L, Traş, B., (2002). Phenobarbital Effects on Brain and Liver Tissues Enzyme Activity in Balb/c Mice. Acta Veterinaria Brno, 71(3), 309-312. Doi: 10.2754/avb200271030309
dc.identifier.doi10.2754/avb200271030309en_US
dc.identifier.endpage312en_US
dc.identifier.issn0001-7213en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://dx.doi.org/10.2754/avb200271030309
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18012
dc.identifier.volume71en_US
dc.identifier.wosWOS:000178403400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYazar, Enver
dc.institutionauthorDemir, O.
dc.institutionauthorElmas, Muammer
dc.institutionauthorBaş, Ahmet Levent
dc.institutionauthorTraş, Bünyamin
dc.language.isoenen_US
dc.publisherVYSOKA SKOLA VETERINARNI FARMACEUTICKAen_US
dc.relation.ispartofActa Veterinaria Brnoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectphenobarbitalen_US
dc.subjectliveren_US
dc.subjectbrainen_US
dc.subjectenzymeen_US
dc.subjectmouseen_US
dc.titlePhenobarbital Effects on Brain and Liver Tissues Enzyme Activity in Balb/c Miceen_US
dc.typeArticleen_US

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