Elit Taekwondocularda C Vitamini Uygulamasının IFN-?, TNF-?, IL-2 ve IL-6 Düzeylerine Etkisi
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Tarih
2018 Ocak
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı, taekwondo sporu yapan bireylerde C vitamini uygulamasının sitokin salınımı üzerindeki etkilerinin araştırılmasıdır. Gereç ve Yöntem: Bu araştırma Selçuk Üniversitesi Beden Eğitimi ve Spor Yüksekokulunda okuyan yaş ortalaması; 20.67±0.24 yıl, vücut ağırlığı ortalaması; 65.45±1.69 kg olan 10 adet erkek elit taekwondocu üzerinde gerçekleştirildi. Deneklere 4 hafta süreyle günde oral olarak 300 mg C vitamini tablet şeklinde verildi ve 4 haftalık vitamin ilavesi öncesi ve sonrası olmak üzere iki kez yorgunluk oluşuncaya kadar tükenme egzersizi yaptırıldı. Dört hafta süren uygulama öncesinde ve sonrasında deneklerden istirahat ve yorgunluk olmak üzere 4 kez kan örnekleri alındı. Alınan kan örneklerinde serumda interferon gama (IFN-?), tümör nekrosiz faktör-alfa (TNF-?), interlökin-2 (IL-2) ve interlökin-6 (IL-6) düzeyleri ELISA test kitleri kullanılarak tayin edildi. Bulgular: IFN-?, TNF-? ve IL-2 düzeyleri hem uygulama öncesi hem de sonrası anlamlı bir farklılık göstermedi (p>0.05). Uygulamadan önceki egzersiz periyodunda serum IL-6 düzeylerinde dinlenme periyoduna göre anlamlı artış vardı (p<0.05). Uygulamadan önceki egzersiz periyodunda ortaya çıkan IL-6 düzeylerindeki artış C vitamini uygulamasıyla önlendi. Sonuç: Çalışmanın sonuçları taekwondo sporu yapan bireylerde C vitamini uygulamasının serum IFN-?, TNF-? ve IL-2 düzeylerini etkilemediğini, ancak egzersizde artan ve bağışıklık fonksiyonları üzerinde inhibe edici etkiye sahip olan IL-6 düzeylerindeki artışı engellediğini göstermektedir.
Objective: The aim of this study was to investigate the effects of vitamin C application on secretion of cytokine in individuals who do taekwondo sport. Materials and Methods: This research was carried out on 10 elite taekwondo athletes who were studying in Selçuk University, School of Physical Education and Sports. Their mean age; 20.67±0.24 years and mean body weight was; 65.45±1.69 kg. Every day 300 mg vitamin C was given to the participants orally during 4 weeks and exhaustive exercise was done until fatigue occurs before and after vitamin E treatment. Before and following the 4 week implementation period, blood samples were taken 4 times from the participants as at rest and fatigue. Interferon gamma (IFN-?), tumour necrosis factor-alpha (TNF-?), interleukin -2 (IL-2) and interleukin -6 (IL6) levels were determined by ELISA test kits on taken blood samples. Results: There were no significant differences on the levels of IFN-?, IL-2 and TNF-? both before and after implementation. There was significant increase on the levels of serum IL-6 at exercise period in comparison with resting period (P<0.05). This increase in on the levels of serum IL-6 at exercise period prior to implementation was prevented by vitamin C application. Conclusion: Results indicated that; vitamin C application did not lead to significant changes on the levels of IFN-?, TNF-? and IL-2 on individuals who practice taekwondo sport. However, it inhibits the increase in levels of IL-6 at exercise that leads to suppression of cellular immune function.
Objective: The aim of this study was to investigate the effects of vitamin C application on secretion of cytokine in individuals who do taekwondo sport. Materials and Methods: This research was carried out on 10 elite taekwondo athletes who were studying in Selçuk University, School of Physical Education and Sports. Their mean age; 20.67±0.24 years and mean body weight was; 65.45±1.69 kg. Every day 300 mg vitamin C was given to the participants orally during 4 weeks and exhaustive exercise was done until fatigue occurs before and after vitamin E treatment. Before and following the 4 week implementation period, blood samples were taken 4 times from the participants as at rest and fatigue. Interferon gamma (IFN-?), tumour necrosis factor-alpha (TNF-?), interleukin -2 (IL-2) and interleukin -6 (IL6) levels were determined by ELISA test kits on taken blood samples. Results: There were no significant differences on the levels of IFN-?, IL-2 and TNF-? both before and after implementation. There was significant increase on the levels of serum IL-6 at exercise period in comparison with resting period (P<0.05). This increase in on the levels of serum IL-6 at exercise period prior to implementation was prevented by vitamin C application. Conclusion: Results indicated that; vitamin C application did not lead to significant changes on the levels of IFN-?, TNF-? and IL-2 on individuals who practice taekwondo sport. However, it inhibits the increase in levels of IL-6 at exercise that leads to suppression of cellular immune function.
Açıklama
Anahtar Kelimeler
Vitamin C, sitokinler, egzersiz, yorgunluk, Taekwondo, Cytokines, Exercise, Fatigue
Kaynak
Selçuk Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
1
Künye
Patlar, S., Boyalı, E., Baltacı, S. B., Moğulkoç, R., Baltacı, A. K., (2018). Elit Taekwondocularda C Vitamini Uygulamasının IFN-γ, TNF-α, IL-2 ve IL-6 Düzeylerine Etkisi. Selçuk Genel Tıp Dergisi, 28(1), 23-27.
