Efficacy of Collagen Membrane Seeded With Autologous Gingival Fibroblasts in Gingival Recession Treatment: A Randomized, Controlled Pilot Study

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dc.contributor.authorKoseoglu, Serhat
dc.contributor.authorDuran, Ismet
dc.contributor.authorSaglam, Mehmet
dc.contributor.authorBozkurt, S. Buket
dc.contributor.authorKirtiloglu, Osman S.
dc.contributor.authorHakki, Sema S.
dc.date.accessioned2020-03-26T18:41:45Z
dc.date.available2020-03-26T18:41:45Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Gingival recession (GR) is one of the most common esthetic concerns associated with periodontal tissues. Recently, tissue engineering technology has been developed and applied in periodontology for the treatment of GR. The aim of this study is to compare the clinical efficacy of collagen membrane with or without autologous gingival fibroblasts under a coronally advanced flap for root coverage. Methods: In this split-mouth, controlled clinical study, 22 sites are selected from 11 patients with Miller Class I recessions affecting canines or premolars in the maxillary arch. One tooth in each patient was randomized to receive either a collagen membrane (CM) (control group) or a collagen membrane seeded with autologous gingival fibroblasts (CM+GF) (test group) under a coronally advanced flap. Thickness of the gingiva, GR, and percentage of root coverage (PRC) were recorded by a calibrated examiner at baseline and 3, 6, and 12 months postoperatively. Furthermore, GR and PRC were evaluated using photogrammetric analysis at baseline and 3, 6, and 12 months. Results: Both treatments resulted in a significant gain in root coverage compared with baseline. A statistically significant increase was detected in PRC in the test group compared with the control group. No significant difference was noted between the test and control sites regarding the thickness of the gingiva. Conclusions: The results indicated that CM+GF prepared by tissue engineering technology can be considered an alternative method for the treatment of Miller Class I recession defects.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey, Ankara, TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-3836 (107S379)]en_US
dc.description.sponsorshipThis study was supported by grants from the Scientific and Technological Research Council of Turkey, Ankara, Turkey [project no. SBAG-3836 (107S379)]. The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1902/jop.2012.120529en_US
dc.identifier.endpage1424en_US
dc.identifier.issn0022-3492en_US
dc.identifier.issn1943-3670en_US
dc.identifier.issue10en_US
dc.identifier.pmid23259414en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1416en_US
dc.identifier.urihttps://dx.doi.org/10.1902/jop.2012.120529
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29458
dc.identifier.volume84en_US
dc.identifier.wosWOS:000328685900011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF PERIODONTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFibroblastsen_US
dc.subjectgingival recessionen_US
dc.subjectguided tissue regenerationen_US
dc.subjectmembranesen_US
dc.subjecttissue engineeringen_US
dc.subjecttransplantation, autologousen_US
dc.titleEfficacy of Collagen Membrane Seeded With Autologous Gingival Fibroblasts in Gingival Recession Treatment: A Randomized, Controlled Pilot Studyen_US
dc.typeArticleen_US

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