Effects of zinc deficiency and pinealectomy on cellular immunity in rats infected with Toxoplasma gondii
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Dosyalar
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
HUMANA PRESS INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effects of zinc and/or melatonin deficiencies on cellular immunity were investigated in rats infected with Toxoplasma gondii. A total of 50 adult male Sprague-Dawley rats were divided into 5 groups of 10 rats each. In group 1, the rats were infected with T gondii and fed a zinc-deficient diet; in group 11, the rats were infected and their pineal gland was surgically removed. Group III included rats that were infected, pinealectomized, and fed a zinc-deficient diet. Group IV consisted of T gondii-infested rats that received no treatment of any kind, and group V were normal controls. After 3 wk of treatment, all rats were sacrificed and the percentages of CD3, CD4, and CD8 lymphocytes, zinc, and melatonin levels in plasma and the percentage of lymphocyte in blood smears were analyzed. The CD3 ratios of groups I-III were significantly lower than those of groups IV and V (p<0.01). The CD4 lymphocytes were significantly higher in group TV than that in all other groups (p<0.05). In group IV, the CD8 lymphocytes were higher than in groups I-III (p<0.01) and those in group V were higher than for groups I and III (p<0.01). Lymphocyte incidence in group IV was higher than in the other four groups (p<0.01). The plasma zinc and plasma melatonin levels in groups I-III were significantly lower than those in the controls (p<0.01, both cases). These results suggest that zinc and/or melatonin deficiency have a negative influence on cellular immunity in rats with toxoplasmosis.
Açıklama
Anahtar Kelimeler
zinc deficiency, pinealectomy, T gondii infection, toxoplasmosis, cellular immunity
Kaynak
BIOLOGICAL TRACE ELEMENT RESEARCH
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
104
Sayı
1
