Effects of zinc deficiency and pinealectomy on cellular immunity in rats infected with Toxoplasma gondii

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dc.contributor.authorBaltaci, AK
dc.contributor.authorMogulkoc, R
dc.contributor.authorBediz, CS
dc.contributor.authorPekel, A
dc.date.accessioned2020-03-26T16:57:05Z
dc.date.available2020-03-26T16:57:05Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of zinc and/or melatonin deficiencies on cellular immunity were investigated in rats infected with Toxoplasma gondii. A total of 50 adult male Sprague-Dawley rats were divided into 5 groups of 10 rats each. In group 1, the rats were infected with T gondii and fed a zinc-deficient diet; in group 11, the rats were infected and their pineal gland was surgically removed. Group III included rats that were infected, pinealectomized, and fed a zinc-deficient diet. Group IV consisted of T gondii-infested rats that received no treatment of any kind, and group V were normal controls. After 3 wk of treatment, all rats were sacrificed and the percentages of CD3, CD4, and CD8 lymphocytes, zinc, and melatonin levels in plasma and the percentage of lymphocyte in blood smears were analyzed. The CD3 ratios of groups I-III were significantly lower than those of groups IV and V (p<0.01). The CD4 lymphocytes were significantly higher in group TV than that in all other groups (p<0.05). In group IV, the CD8 lymphocytes were higher than in groups I-III (p<0.01) and those in group V were higher than for groups I and III (p<0.01). Lymphocyte incidence in group IV was higher than in the other four groups (p<0.01). The plasma zinc and plasma melatonin levels in groups I-III were significantly lower than those in the controls (p<0.01, both cases). These results suggest that zinc and/or melatonin deficiency have a negative influence on cellular immunity in rats with toxoplasmosis.en_US
dc.identifier.doi10.1385/BTER:104:1:047en_US
dc.identifier.endpage56en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issue1en_US
dc.identifier.pmid15851832en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://dx.doi.org/10.1385/BTER:104:1:047
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19714
dc.identifier.volume104en_US
dc.identifier.wosWOS:000228961800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectzinc deficiencyen_US
dc.subjectpinealectomyen_US
dc.subjectT gondii infectionen_US
dc.subjecttoxoplasmosisen_US
dc.subjectcellular immunityen_US
dc.titleEffects of zinc deficiency and pinealectomy on cellular immunity in rats infected with Toxoplasma gondiien_US
dc.typeArticleen_US

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