Association of vesicoureteral reflux and renal scarring in urinary tract infections

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dc.contributor.authorYilmaz, Isa
dc.contributor.authorPeru, Harun
dc.contributor.authorYilmaz, Fatma H.
dc.contributor.authorSekmenli, Tamer
dc.contributor.authorCiftci, Ilhan
dc.contributor.authorKara, Fatih
dc.date.accessioned2020-03-26T19:52:57Z
dc.date.available2020-03-26T19:52:57Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction. The aim was to investigate the relationship between vesicoureteral reflux (VUR) and renal damage in non-febrile, febrile for the first time and recurrent urinary tract infection (UTI) patients. The secondary aim was to determine whether C-reactive protein (CRP) in febrile UTIs could be a predictor of renal scarring. Population and methods. This prospective study included non-febrile, febrile for the first time and recurrent pediatric UTI cases. The routine lab analyses comprised a complete blood count, urea, creatinine, fully automated urinalysis, urine culture and CRP analyses. All the participants were examined using urine ultrasonography subsequent to their UTI diagnosis, voiding cystourethrography (VCUG) after six weeks and Tc-99m dimercaptosuccinic acid (DMSA) static renal scintigraphy after six months. Results. There were included 47 children with non-febrile UTIs, 48 with fist febrile UTIs and 61 with recurrent UTIs. A statistically significant difference was found among the groups in terms of VUR and renal scarring (p = 0.001 and p = 0.011, respectively). A statistically significant difference was also found in terms of renal scarring between patients with and without VUR (p = 0.001). Moreover, a statistically significant difference was also present in relation to renal scarring (p<0.05)in patients with five-fold lower or higher CRP values than the accepted cut-off value (5mg/dl). Conclusion. The ratio of renal scars detected was found to be parallel to the VUR frequency. The higher the VUR grade, the more renal damage was found. A positive correlation between elevated CRP and renal scarring was determined, indicating the presence of scarring during the diagnosis of pyelonephritis.en_US
dc.identifier.doi10.5546/aap.2018.eng.e542en_US
dc.identifier.endpageE547en_US
dc.identifier.issn0325-0075en_US
dc.identifier.issn1668-3501en_US
dc.identifier.issue4en_US
dc.identifier.pmid30016028en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE542en_US
dc.identifier.urihttps://dx.doi.org/10.5546/aap.2018.eng.e542
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36351
dc.identifier.volume116en_US
dc.identifier.wosWOS:000439814600014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSOC ARGENTINA PEDIATRIAen_US
dc.relation.ispartofARCHIVOS ARGENTINOS DE PEDIATRIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectvesico-ureteral refluxen_US
dc.subjectchilden_US
dc.subjectrenal scarringen_US
dc.subjecturinary tract infectionsen_US
dc.titleAssociation of vesicoureteral reflux and renal scarring in urinary tract infectionsen_US
dc.typeArticleen_US

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