Static magnetic field inhibits 5 ' nucleotidase activity in cancerous and non-cancerous human gastric tissues

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dc.contributor.authorDurak, Zahide Esra
dc.contributor.authorBuber, Suleyman
dc.contributor.authorKocaoglu, Ender Hilmi
dc.contributor.authorOzturk, Bahadir
dc.date.accessioned2020-03-26T19:26:36Z
dc.date.available2020-03-26T19:26:36Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the present study is to investigate possible effects of static magnetic field (SMF) on 5 nucleotidase (5NT-CD73) and xanthine oxidase (XO) activities in cancerous and non-cancerous human gastric tissues in order to contribute to the elucidation of the anticancer activity of SMF. Cancerous and non-cancerous human gastric tissues removed from patients by surgical operations were used in the studies. SMF was created using two static magnets. Before and after treatment with SMF, 5NT and XO activities in the tissue samples were measured. 5NT activity was found to be lowered, but no significant change was observed in XO activity in the gastric tissues treated with the SMF. Our results suggest that SMF inhibits 5NT enzyme in gastric tissues significantly. It is supposed that in addition to other proposed mechanisms, inhibition of purine catabolic activity due to inhibition of some key enzymes in the DNA turn-over like 5NT might also play part in the anticancer activity of SMF.en_US
dc.identifier.doi10.3109/15368378.2014.977389en_US
dc.identifier.endpage58en_US
dc.identifier.issn1536-8378en_US
dc.identifier.issn1536-8386en_US
dc.identifier.issue1en_US
dc.identifier.pmid25372949en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://dx.doi.org/10.3109/15368378.2014.977389
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34029
dc.identifier.volume35en_US
dc.identifier.wosWOS:000369499800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofELECTROMAGNETIC BIOLOGY AND MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCanceren_US
dc.subject5 nucleotidaseen_US
dc.subjectstatic magnetic fielden_US
dc.subjectxanthine oxidaseen_US
dc.titleStatic magnetic field inhibits 5 ' nucleotidase activity in cancerous and non-cancerous human gastric tissuesen_US
dc.typeArticleen_US

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