Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys

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dc.contributor.authorGabelt, B'Aan True
dc.contributor.authorHennes, Elizabeth A.
dc.contributor.authorBendel, Mark A.
dc.contributor.authorConstant, Chase E.
dc.contributor.authorOkka, Mehmet
dc.contributor.authorKaufman, Paul L.
dc.date.accessioned2020-03-26T17:45:52Z
dc.date.available2020-03-26T17:45:52Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine whether the magnitude of the intraocular-pressure (IOP)-lowering response in monkeys to the nonselective prostaglandin (PG)F2a-isopropyl ester (ie) can be reproduced by combining other PG-subtype-selective compounds. IOP was lowered by approximately 25% after 4-5 days of topical administration with latanoprost (FP agonist, 1.5 ?g, q.d.), bimatoprost (prostamide, whose metabolites have been shown to be FP agonists; 9 ?g, q.d.), or travoprost (FP agonist, 1.2 ?g, q.d) or the EP2 agonist, butaprost (25 ?g, b.i.d.). The EP1 agonist, 17-phenyl trinor (PhT) PGE2 (b.i.d.), and EP3 agonist, sulprostone (b.i.d.), had no IOP-lowering effects. The addition of butaprost, sulprostone (10 ?g), or 17PhTPGE2 (25 ?g) to latanoprost did not lower IOP more than latanoprost alone. However, treatment with the combination of latanoprost, 17PhTPGE2, butaprost, and sulprostone produced a similar 50-55% reduction in IOP, as did PGF 2?-ie (b.i.d.). In conclusion, latanoprost, travoprost, and bimatoprost produce similar IOP-lowering responses in normotensive monkeys and are most efficacious when administered q.d. pm, compared to b.i.d. The combination of the FP, EP1, EP2, and EP3 agonists used in this study was sufficient to lower IOP by the same magnitude as PGF2?-ie, suggesting that combining PG-subtype agonists may be a potent antiglaucoma strategy.en_US
dc.identifier.citationGabelt, B. T., Hennes, E. A., Bendel, M. A., Constant, C. E., Okka, M., Kaufman, P. L., (2009). Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys. Journal of Ocular Pharmacology and Therapeutics, 25(1), 1-8. Doi: 10.1089/jop.2008.0089
dc.identifier.doi10.1089/jop.2008.0089en_US
dc.identifier.endpage8en_US
dc.identifier.issn1080-7683en_US
dc.identifier.issue1en_US
dc.identifier.pmid19232013en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1089/jop.2008.0089
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24178
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOkka, Mehmet
dc.language.isoenen_US
dc.relation.ispartofJournal of Ocular Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleProstaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeysen_US
dc.typeArticleen_US

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