Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation

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dc.contributor.authorÖztekin, Esma
dc.contributor.authorTiftik, Ali Muhtar
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T17:17:38Z
dc.date.available2020-03-26T17:17:38Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study aimed to determine the effect of estradiol-progesterone supplementation and pinealectomy on lipid peroxidation of liver tissue in ovariectomized rats. The study was carried out on 36 adult Sprague-Dawley female rats, which weighed 200-250 g. The rats were divided into 6 groups: Group 1: Sham Ovariectomy (Sham-Ovx), Group 2: Ovariectomy (Ovx), Group 3: Ovx + Estradiol-Progesterone supplementation (Ovx + H), Group 4: Sham Pinealectomy and Ovx (Sham Pnx -Ovx), Group 5: Ovx -Pnx, Group 6: Ovx -Pnx + H. Malondialdehyde (MDA), reduced form of glutathione (GSH) and glutathione peroxidase (GSH-Px) levels were determined in liver tissue of rats. The highest MDA levels and the lowest GSH-Px levels were determined in the ovariectomized-pinealectomized group, whereas the lowest MDA was in the Sham-Ovx group, and the highest GSH-Px levels were found in the Sham-Ovx and Ovx + Hormone supplemented group. Furthermore, the highest GSH levels were in group 1 and lowest levels were in group 5. The findings of this study demonstrate that ovariectomy led to lipid peroxidation in liver tissues of rats. Pinealectomy in addition to ovariectomy, increases lipid peroxidation, but, estradiol and progesterone supplementations to the ovariectomized-pinealectomized rats protect against lipid peroxidation to a significant extent. Copyright (C) 2006 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1313en_US
dc.identifier.endpage405en_US
dc.identifier.issn0263-6484en_US
dc.identifier.issn1099-0844en_US
dc.identifier.issue4en_US
dc.identifier.pmid16444765en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cbf.1313
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21459
dc.identifier.volume25en_US
dc.identifier.wosWOS:000248157500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCELL BIOCHEMISTRY AND FUNCTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectovariectomyen_US
dc.subjectpinealectomyen_US
dc.subjectestrogen and progesterone supplementationen_US
dc.titleLipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementationen_US
dc.typeArticleen_US

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