The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

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dc.contributor.authorDalkilic, Nizamettin
dc.contributor.authorTuncer, Seckin
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorKiziltanc, Erhan
dc.date.accessioned2020-03-26T17:40:36Z
dc.date.available2020-03-26T17:40:36Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to document the effect of tramadol as an opioid on individual fibers of rat sciatic nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated nerves treated with tramadol from five different concentration levels. Then recorded CAPs and the control group were analyzed by numerical methods namely Conduction Velocity Distribution (CVD) and Fast Fourier Transform (FFT). The results show that the area under CAP and the time derivative of CAP curves decreases, and the excitability of the nerve trunk falls as well (rheobase and chronaxie increases) with increasing tramadol concentration. CVD deduced by model study was divided into subgroups as SLOW (8-26 m/s), MODERATE (26-44 m/s), MEDIUM (44-60 m/s) and FAST (60-78 m/s). The decrement in percentage relative contribution of these conduction velocity groups starts with a concentration of 0.25 mM tramadol, especially in the subgroup named FAST. The power spectrum shifts from higher frequency region to lower frequency region as the tramadol concentration increases. These findings show that fast conducting fibers are more susceptible to tramadol than medium and moderate groups and tramadol possibly acts on channel activity rather than passive properties (such as space and time constant) of nerve fibers.en_US
dc.identifier.doi10.1248/yakushi.129.485en_US
dc.identifier.endpage493en_US
dc.identifier.issn0031-6903en_US
dc.identifier.issue4en_US
dc.identifier.pmid19337003en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage485en_US
dc.identifier.urihttps://dx.doi.org/10.1248/yakushi.129.485
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23929
dc.identifier.volume129en_US
dc.identifier.wosWOS:000264618100014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPHARMACEUTICAL SOC JAPANen_US
dc.relation.ispartofYAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPANen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcompound action potentialen_US
dc.subjectconduction velocity distributionen_US
dc.subjecttramadolen_US
dc.subjectrat sciatic nerveen_US
dc.titleThe Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Studyen_US
dc.typeArticleen_US

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