Relationship between color M-mode echocardiography flow propagation and cardiac iron load on MRI in patients with thalassemia major

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dc.contributor.authorOzbek, Orhan
dc.contributor.authorAcar, Kadir
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorOzbek, Seda
dc.contributor.authorGul, Enes Elvin
dc.contributor.authorUcar, Ramazan
dc.contributor.authorPaksoy, Yahya
dc.date.accessioned2020-03-26T18:31:12Z
dc.date.available2020-03-26T18:31:12Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPURPOSE Myocardial iron overload remains an important problem and results in cardiac dysfunction in patients with thalassemia major (TM). The ratio of color M-mode flow propagation velocity to early diastolic transmitral flow velocity (E/Vp) in echocardiography is a marker of increased left ventricular filling pressure, which is independent of preload, afterload, and heart rate. We examined the relationship between E/Vp and iron loading in patients with TM using cardiac magnetic resonance imaging (MRI). MATERIALS AND METHODS Twenty-one TM patients and 21 age-matched healthy controls were enrolled in the study. Transmitral flow, pulmonary vein velocities, and Vp were obtained by two blinded echocardiographers. Left ventricular isovolumetric relaxation time (IVRT) was measured in the apical long axis by echocardiography. All patients also underwent MRI for cardiac T2* evaluation of iron overload. An increased E/Vp was defined as >1.5. RESULTS The E/Vp ratio was increased in TM patients compared with control subjects (1.7+/-0.4 and 1.2+/-0.2, P < 0.01, respectively). There was no correlation between E/Vp and cardiac T2* value. E/Vp was significantly correlated with IVRT (r=0.51, P = 0.02). In addition, the cardiac T2* value was comparable in patients with an E/Vp >1.5 and E/Vp <= 1.5 (21.1+/-9.8 ms vs. 22.3+/-8.0 ms, P = 0.80, respectively). CONCLUSION E/Vp may be a marker of diastolic abnormality that is independent from myocardial iron load in TM patients with preserved left ventricular function.en_US
dc.identifier.doi10.4261/1305-3825.DIR.4581-11.1en_US
dc.identifier.endpage214en_US
dc.identifier.issn1305-3825en_US
dc.identifier.issue2en_US
dc.identifier.pmid22006577en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://dx.doi.org/10.4261/1305-3825.DIR.4581-11.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28363
dc.identifier.volume18en_US
dc.identifier.wosWOS:000302206300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH SOC RADIOLOGYen_US
dc.relation.ispartofDIAGNOSTIC AND INTERVENTIONAL RADIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectthalassemia majoren_US
dc.subjectiron overloaden_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectDoppler echocardiographyen_US
dc.titleRelationship between color M-mode echocardiography flow propagation and cardiac iron load on MRI in patients with thalassemia majoren_US
dc.typeArticleen_US

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