P53 expression between 13-27 weeks old human male fetus gonads

Basit Öğe Kaydı
dc.contributor.authorTosun, Murat
dc.contributor.authorTosun, Emine
dc.contributor.authorKalkan, Serpil
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2020-03-26T17:17:50Z
dc.date.available2020-03-26T17:17:50Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractP53 is a tumor suppressor gene and a critical component of cellular mechanisms that respond to genotoxic stresses. During normal fetal development, some of these cells lose their genomic stability because of intensive cell proliferation. They arrest cell cycle progression and repair genomic stability by p53 induction or die via apoptosis. If p53 is overexpressed, some structures may have different abnormalities. This study was conducted to investigate normal p53 expression in human male gonads during second trimester. Twenty one normal human male fetuses' testes in 2nd trimester were processed and immunohistochemistry was applied. The spermatogonia with nuclear and perinuclear staining, were accepted as p53 (+). The number of p53 (+) spermatogonia was counted in randomly 10 different seminiferous tubules. The results suggest that p53 expression in gonads of human male fetuses significantly increases in the 20th week.en_US
dc.identifier.doi10.1007/s10735-007-9097-2en_US
dc.identifier.endpage274en_US
dc.identifier.issn1567-2379en_US
dc.identifier.issue4en_US
dc.identifier.pmid17653608en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10735-007-9097-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21514
dc.identifier.volume38en_US
dc.identifier.wosWOS:000248328300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF MOLECULAR HISTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectspermatogoniaen_US
dc.subjectP53en_US
dc.subjectfetusen_US
dc.subjectdevelopmenten_US
dc.subjectembryologyen_US
dc.titleP53 expression between 13-27 weeks old human male fetus gonadsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu