Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise

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dc.contributor.authorBiçer, Mürsel
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorPatlar, Süleyman
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.date.accessioned2020-03-26T19:54:39Z
dc.date.available2020-03-26T19:54:39Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The present study aimed to examine the effects of melatonin supplementation on lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise. Methods: The study was conducted on 80 Sprague-Dawley type adult male rats which were equally allocated to eight groups: group 1, general control; group 2, melatonin-supplemented control; group 3, melatonin-supplemented diabetic control; group 4, swimming control; group 5, melatonin-supplemented swimming; group 6, melatonin-supplemented diabetic swimming; group 7, diabetic swimming; group 8, diabetic control. In order to induce diabetes, the animals were subcutaneously injected with 40 mg/kg streptozotocin (STZ). The animals were supplemented with 3 mg/kg/day melatonin intraperitoneally (IP) for 4 weeks. At the end of the study, the animals were decapitated to collect bone tissue samples which were examined to find out the malondialdehyde (MDA) (nmol/g/protein) and glutathione (GSH) (mg/dL/g protein) levels. Results: The highest MDA values in the bone tissue were found in groups 7 and 8. MDA levels in the bone tissue in groups 3 and 6 were lower than the levels in groups 7 and 8, but higher than those in all other groups. Groups 3, 5 and 6 had the highest bone tissue GSH values. On the other hand, the lowest GSH level was established in groups 7 and 8. Conclusion: The results of the present study indicated that the cell damage caused by acute swimming exercise and diabetes in the bone tissue could be prevented by melatonin supplementation.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University (SUBAPK)Selcuk University [08401082]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 08401082).en_US
dc.identifier.doi10.1515/hmbci-2017-0079en_US
dc.identifier.issn1868-1883en_US
dc.identifier.issn1868-1891en_US
dc.identifier.issue2en_US
dc.identifier.pmid29547389en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1515/hmbci-2017-0079
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36770
dc.identifier.volume34en_US
dc.identifier.wosWOS:000435876900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofHORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbone tissueen_US
dc.subjectdiabetic ratsen_US
dc.subjectexerciseen_US
dc.subjectlipid peroxidationen_US
dc.subjectmelatonin supplementationen_US
dc.titleMelatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exerciseen_US
dc.typeArticleen_US

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