Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits

Basit Öğe Kaydı
dc.contributor.authorElmas, M
dc.contributor.authorYazar, E
dc.contributor.authorUney, K
dc.contributor.authorKarabacak, A
dc.date.accessioned2020-03-26T17:04:01Z
dc.date.available2020-03-26T17:04:01Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe pharmacokinetics of flunixin were determined after intravenous bolus injection at a single dose (2.2 mg/kg) in healthy rabbits and diseased rabbits with Escherichia coli lipopolysaccharide-induced septic shock. Six adult New Zealand White rabbits were used. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were best described by a two-compartment open model. In healthy rabbits, there was a high plasma clearance (0.62 L/(h kg)), and a relatively short elimination half-life (1.19 h). In endotoxaemic rabbits, total plasma clearance (0.43 L/(h kg)) was significantly lower (p < 0.05), and elimination half-life (1.90 h) and AUC(0-infinity) (5.29 (mu g h)/ml) were significantly higher (p < 0.05) than in healthy animals. The changes of pharmacokinetics of flunixin in rabbits with septic shock could be of clinical significance, and may require monitoring of plasma flunixin levels in endotoxaemic status.en_US
dc.identifier.doi10.1007/s11259-005-3227-7en_US
dc.identifier.endpage81en_US
dc.identifier.issn0165-7380en_US
dc.identifier.issn1573-7446en_US
dc.identifier.issue1en_US
dc.identifier.pmid16362612en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11259-005-3227-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20610
dc.identifier.volume30en_US
dc.identifier.wosWOS:000234026400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofVETERINARY RESEARCH COMMUNICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectendotoxaemiaen_US
dc.subjectflunixinen_US
dc.subjectlipopolysaccharideen_US
dc.subjectpharmacokineticsen_US
dc.subjectrabbitsen_US
dc.titlePharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbitsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu