GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

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dc.contributor.authorCeylan, Ramazan
dc.contributor.authorZengin, Gökhan
dc.contributor.authorUysal, Şengül
dc.contributor.authorİlhan, Veli
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorKandemir, Ali
dc.contributor.authorAnwar, Farooq
dc.date.accessioned2020-03-26T19:24:21Z
dc.date.available2020-03-26T19:24:21Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the antioxidant and enzyme inhibitory activities and chemical composition of the hydro-distilled essential oil (0.35% yield) from aerial parts of Thymus spathulifolius. Antioxidant capacity of the oil was assessed by different methods including free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC) and phosphomolybdenum assay. Inhibitory activities were analyzed against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-amylase, alpha-glucosidase, and tyrosinase. Twenty-one constituents were identified representing 97.2% of the total oil with thymol (50.5%), borneol (16.7%) and carvacrol (7.7%) as the major components. The essential oil exhibited good antioxidant activity with IC50 values of 3.82 and 0.22 mg/mL determined by free radical scavenging DPPH and ABTS, respectively. EC50 values of FRAP and CUPRAC were found to be 0.12 and 0.34 mg/mL, respectively. The results of the present study support the uses of T. spathulifolius essential oil as a source of natural antioxidants and bioactivities for functional foods and phytomedicines.en_US
dc.identifier.doi10.3109/14756366.2015.1077822en_US
dc.identifier.endpage990en_US
dc.identifier.issn1475-6366en_US
dc.identifier.issn1475-6374en_US
dc.identifier.issue6en_US
dc.identifier.pmid26327330en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage983en_US
dc.identifier.urihttps://dx.doi.org/10.3109/14756366.2015.1077822
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33636
dc.identifier.volume31en_US
dc.identifier.wosWOS:000385270300016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectenzyme inhibitionen_US
dc.subjectthymolen_US
dc.subjectThymus spathulifoliusen_US
dc.titleGC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velenen_US
dc.typeArticleen_US

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