The effect of endodontic therapy on periapical exudate neutrophil elastase and prostaglandin-E-2 levels

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dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorArı, Hale
dc.contributor.authorHaliloğlu, Seyfullah
dc.contributor.authorAlptekin, Tuncay
dc.contributor.authorSerpek, Behiç
dc.contributor.authorAtaoğlu, Tamer
dc.date.accessioned2020-03-26T16:58:10Z
dc.date.available2020-03-26T16:58:10Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aimed to investigate periapical exudate neutrophil elastase (NE) and prostaglandin E-2 (PGE(2)) levels and their relationships with clinical symptoms, and to determine the changes of their levels following first treatment visit. Periapical exudate samples were collected from the canals of 34 nonvital single-rooted teeth at two sequential treatment visits. Periapical exudate NE and PGE(2) levels were found to be higher in the presence of clinical symptoms (pus discharge, swelling) (p < 0.05). The canals of teeth with larger periapical radiolucent area (>= 1 cm) contained more PGE(2) levels than with smaller ones (< 1 cm) (p < 0.05). Periapical exudate NE levels were significantly correlated with PGE2 levels (p < 0.05), and their levels at first treatment visit did not change following root canal therapy (p > 0.05). The periapical exudate NE and PGE(2) levels may regulate periapical disease expression, but the results of this study were unable to reveal this association.en_US
dc.identifier.doi10.1097/01.don.0000158010.43884.59en_US
dc.identifier.endpage795en_US
dc.identifier.issn0099-2399en_US
dc.identifier.issn1878-3554en_US
dc.identifier.issue11en_US
dc.identifier.pmid16249720en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage791en_US
dc.identifier.urihttps://dx.doi.org/10.1097/01.don.0000158010.43884.59
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19912
dc.identifier.volume31en_US
dc.identifier.wosWOS:000232931700003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofJOURNAL OF ENDODONTICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectneutrophil elastaseen_US
dc.subjectPGE(2)en_US
dc.subjectperiapical periodontitisen_US
dc.subjectperiapical exudateen_US
dc.titleThe effect of endodontic therapy on periapical exudate neutrophil elastase and prostaglandin-E-2 levelsen_US
dc.typeArticleen_US

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