Warming and response to contractile agents in calf cardiac vein: Role of the Ca2+, K-Ca(2+), and Na+ ion channel blockers

dc.contributor.authorAtalik, KE
dc.contributor.authorSahin, AS
dc.contributor.authorDogan, N
dc.date.accessioned2020-03-26T16:58:30Z
dc.date.available2020-03-26T16:58:30Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of wartning (to 41 degrees C) oil the serotonin (5-HT, 10(-8)-3 x 10(-3) M)- and carbachol (10(-9)-3 x 10(-4) M)-induced contractions and the role of calcium (Ca2+). potassium (K+), and sodium (Na+) channel blockers, in the warming-induced responses were investigated in the calf cardiac vein. Concentration-response curves to 5-HT and carbachol were isometrically recorded at 37 and 41 degrees C (control). The same procedure was repeated at 41 degrees C in the presence of verapamil (10(-6) M), caffeine (3 x 10(-4) M), tetraethylammonium (TEA, 10(-3) M), flecainide (10(-6) M), and also in the Ca2+-free medium with ethlylene glycol bis(beta-aminoethyl ether) N,N,N',N'-tetraacetic acid (EGTA). During warning, the sensitivity, but not the maximum response, was significantly higher. Warming to 41 degrees C after treatment with verapamil or flecainide decreased the sensitivity, whereas treatment with caffine increased the sensitivity significantly. Treatment with TEA (lid not modify the effect of warming. Furthermore, warming to 41 degrees C after incubation in Ca2+-free solutions with EGTA decreased the sensitivity to 5-HT and carbachol. The results of this study suggest the role for Ca2+ and Na+ ions in the warming-induced changes of cardiac vein treated with 5-HT and carbachol. (c) 2005 Prous Science. All right reserved.en_US
dc.identifier.doi10.1358/mf.2005.27.9.939342en_US
dc.identifier.endpage657en_US
dc.identifier.issn0379-0355en_US
dc.identifier.issn2013-0155en_US
dc.identifier.issue9en_US
dc.identifier.pmid16357951en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://dx.doi.org/10.1358/mf.2005.27.9.939342
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19968
dc.identifier.volume27en_US
dc.identifier.wosWOS:000234147400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPROUS SCIENCE, SAU-THOMSON REUTERSen_US
dc.relation.ispartofMETHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCa2+en_US
dc.subjectK-Ca(2+)en_US
dc.subjectand Na+ ion channel blockersen_US
dc.subjectcardiac veinen_US
dc.subjectwarmingen_US
dc.titleWarming and response to contractile agents in calf cardiac vein: Role of the Ca2+, K-Ca(2+), and Na+ ion channel blockersen_US
dc.typeArticleen_US

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