Identification of phenolic components via LC-MS analysis and biological activities of two centaurea species: c. drabifolia subsp drabifolia and c. iycopifolia

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorGevrenova, Reneta
dc.contributor.authorNedialkov, Paraskev
dc.contributor.authorMocan, Andrei
dc.contributor.authorCiric, Ana
dc.contributor.authorGlamoclija, Jasmina
dc.contributor.authorSokovic, Marina
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorMahomoodall, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:54:13Z
dc.date.available2020-03-26T19:54:13Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü.en_US
dc.description.abstractThe Centaurea genus has great potential in traditional systems and has attracted much interest in the design of novel drug formulations. The present study was focused on the chemical fingerprints and biological properties of Centaurea drabifolia subsp. drabifolia and Centaurea lycopifolia extracts. Spectrophotometri c and LC-MS techniques were used to establish the chemical profiles of the studied extracts. Enzyme inhibitory potential was assessed against key enzymes linked to global health problems, namely neurodegenerative diseases (acetylcholinesterase), pigmentation (tyrosinase), and diabetes (alpha-amylase and alpha-glucosidase). The antimicrobial propensities of the extract were evaluated against 16 bacterial and fungal strains using the microdilution method. The antioxidant abilities were assessed using DPPH and ABTS radical scavenging, ferric, and cupric reducing powers, phosphomolybdenum, and ferrous metal chelation. The total phenolic compounds varied from 18.33 to 32.84 nigGAE/gextract.Total flavonoid content of the extracts were in the range of 2.88-22.39 mgRE/g extract. Methanol and water extracts showed stronger antioxidant abilities compared to the ethyl acetate extracts. However, the latter extracts were most efficient towards the target enzymes (except for tyrosinase). The water extracts also exerted considerable antimicrobial effects. Findings from the present work tend to support the idea that C. drabifolia subsp. drabifolia and C lycopifolia may be utilized as effective bio-resources for designing novel health promoting products or ingredients. It is anticipated that results amassed from this still will open new avenues for research and contribute towards establishing primary data on these species for designing novel phytopharmaceuticals. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipSerbian Ministry of Education, Science and Technological Development [173032]en_US
dc.description.sponsorshipThe authors are grateful to Serbian Ministry of Education, Science and Technological Development for financial support (grant number 173032).en_US
dc.identifier.citationZengin, G., Dimitrova, D. Z., Gevrenova, R., Nedialkov, R., Mocan, A., Ciric, A., Glamoclija, J., Sokovic, M., Aktümsek, A., Mahomoodally, M. F. (2018). Identification of Phenolic Components Via LC-MS Analysis and Biological Activities of Two Centaurea Species: C. Drabifolia Subsp Drabifolia and C. Lycopifolia. Journal of Pharmaceutical and Biomedical Analysis, 149, 436-441.
dc.identifier.doi10.1016/j.jpba.2017.11.045en_US
dc.identifier.endpage441en_US
dc.identifier.issn0731-7085en_US
dc.identifier.issn1873-264Xen_US
dc.identifier.pmid29169111en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpba.2017.11.045
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36687
dc.identifier.volume149en_US
dc.identifier.wosWOS:000424315700055en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCentaureaen_US
dc.subjectPhenolicsen_US
dc.subjectBiological effectsen_US
dc.subjectNatural bioactive agentsen_US
dc.subjectFunctional productsen_US
dc.titleIdentification of phenolic components via LC-MS analysis and biological activities of two centaurea species: c. drabifolia subsp drabifolia and c. iycopifoliaen_US
dc.typeArticleen_US

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