Assessment of concomitant versus sequential trastuzumab on radiation-induced cardiovascular toxicity

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dc.contributor.authorYavas, G.
dc.contributor.authorGultekin, M.
dc.contributor.authorYildiz, O.
dc.contributor.authorSeyrek, M.
dc.contributor.authorDemirkol, S.
dc.contributor.authorToy, H.
dc.contributor.authorSargon, M. F.
dc.date.accessioned2020-03-26T19:33:59Z
dc.date.available2020-03-26T19:33:59Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThere are limited data regarding effect of trastuzumab on radiation-induced cardiovascular toxicity when used sequentially or concomitantly. This experimental study aims to investigate effect of trastuzumab on radiation-induced cardiovascular toxicity with respect to the treatment sequence. One hundred and eight female Wistar albino rats were divided into six groups (G): G1 was control, G2 was trastuzumab, and G3 was radiotherapy (RT); G4 and G6 were sequential RT and trastuzumab; and G5 was concomitant RT and trastuzumab groups, respectively. Rats were killed at 6th h, 21st and 70th days after RT; thoracic aorta and heart samples were obtained. Transthoracic echocardiography and functional studies evaluating relaxation of thoracic aorta were performed. Subendothelial edema scores of thoracic aorta samples at 21st and 70th days were higher in RT groups (G3, G4, G5, and G6) (p < 0.001). There was a deterioration of relaxation responses of thoracic aorta samples in RT groups (p < 0.001). Cardiac fibrosis (CF) scores revealed detrimental effect of RT beginning from 6th h and trastuzumab from 21st day. RT groups showed further deterioration of CF at 70th day. Ejection fraction, left ventricular mass, and fractional shortening were significantly decreased in G4, G5, and G6. Trastuzumab may increase pathological damage in cardiovascular structures when used with RT regardless of timing.en_US
dc.description.sponsorshipGulhane Military Medical Academy [AR. 2010/73]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by Gulhane Military Medical Academy (AR. 2010/73). There is no role of study sponsors in the study design, in the collection, analysis and interpretation of data, in the writing of the manuscript and in the decision to submit the manuscript for publication.en_US
dc.identifier.doi10.1177/0960327116680276en_US
dc.identifier.endpage1130en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue11en_US
dc.identifier.pmid27932539en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1121en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327116680276
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34819
dc.identifier.volume36en_US
dc.identifier.wosWOS:000412671800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofHUMAN & EXPERIMENTAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCardiovascular toxicityen_US
dc.subjectradiation therapyen_US
dc.subjecttrastuzumaben_US
dc.titleAssessment of concomitant versus sequential trastuzumab on radiation-induced cardiovascular toxicityen_US
dc.typeArticleen_US

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