Effects of Aflatoxin on Liver and Protective Effectiveness of Esterified Glucomannan in Merino Rams

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dc.contributor.authorColakoglu, Fatma
dc.contributor.authorDonmez, Hasan Huseyin
dc.date.accessioned2020-03-26T18:25:08Z
dc.date.available2020-03-26T18:25:08Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe effects of total aflatoxin (AF) given orally on liver in Merino rams were studied. In addition, this study was conducted in order to evaluate the efficacy of an esterified glucomannan (EG) for protection against aflatoxicosis. One-year-old 32 Merino rams were divided into four equal groups. The control group (C) was fed with the commercial feed. The AF group was fed with commercial feed plus 250 mu g/day of total AF. The EG group was fed with commercial feed plus 2 g/day of EG. The AF + EG group was fed with commercial feed plus 250 mu g/day of total AF and 2 g/day of EG. After feeding period, tissue samples were taken from the liver in order to perform histological analyses. Vacuolar degeneration with small and large droplets and hydropic degeneration in hepatocytes were observed in the AF group. The ceroid pigmentation was observed in macrophages in groups or one by one. It was observed that the fat rate in hepatocytes was 2.6% in the C group, 35.5% in the AF group, 2.9% in the EG group, and 9.6% in the AF + EG group. In conclusion, the adverse effects caused by aflatoxicosis on the liver could be ameliorated by adding EG to the ration.en_US
dc.description.sponsorshipTUBITAK-TOVAGTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107 O 866]; Selcuk University (SU BAP Project)Selcuk University [09202023]en_US
dc.description.sponsorshipThe study was supported by TUBITAK-TOVAG (Project no. 107 O 866) and the Coordinatorship of Scientific Research Projects of Selcuk University (SU BAP Project no. 09202023).en_US
dc.identifier.doi10.1100/2012/462925en_US
dc.identifier.issn1537-744Xen_US
dc.identifier.pmid23304087en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1100/2012/462925
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27963
dc.identifier.wosWOS:000312789400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofSCIENTIFIC WORLD JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffects of Aflatoxin on Liver and Protective Effectiveness of Esterified Glucomannan in Merino Ramsen_US
dc.typeArticleen_US

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