Association of apolipoprotein E-219T > G promoter polymorphism with primary open angle glaucoma in Turkish population

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dc.contributor.authorSaglar, Emel
dc.contributor.authorBozkturt, Ranu
dc.contributor.authorIrkec, Murat
dc.date.accessioned2020-03-26T18:49:31Z
dc.date.available2020-03-26T18:49:31Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAIM: To investigate the association between apolipoprotein E (APOE) -219 T >G promoter polymorphism and primary open angle glaucoma(POAG). METHODS: Patients and healthy subjects were genotyped with polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP). Genotype/ allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test. RESULTS: Although the frequency of APOE-219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear CID ratio was higher and progression was more compared to glaucoma patients with GT genotype. CONCLUSION: APOE-219 T >G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.en_US
dc.description.sponsorshipScientific Research Fund of Hacettepe UniversityHacettepe University [0401601001]en_US
dc.description.sponsorshipSupported by Scientific Research Fund of Hacettepe University (No.0401601001)en_US
dc.identifier.doi10.3980/j.issn.2222-3959.2014.03.07en_US
dc.identifier.endpage430en_US
dc.identifier.issn2222-3959en_US
dc.identifier.issn2227-4898en_US
dc.identifier.issue3en_US
dc.identifier.pmid24967185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage426en_US
dc.identifier.urihttps://dx.doi.org/10.3980/j.issn.2222-3959.2014.03.07
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30628
dc.identifier.volume7en_US
dc.identifier.wosWOS:000337658400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIJO PRESSen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectapolipoprotein Een_US
dc.subjectprimary open angle glaucomaen_US
dc.subjectpromoteren_US
dc.subjectsingle nucleotide polymorphismen_US
dc.titleAssociation of apolipoprotein E-219T > G promoter polymorphism with primary open angle glaucoma in Turkish populationen_US
dc.typeArticleen_US

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