The Association Among Lipoprotein-associated Phospholipase A2 Levels, Total Antioxidant Capacity and Arousal in Male Patients with OSA

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dc.contributor.authorBekci, Taha T.
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorKiyici, Aysel
dc.contributor.authorMaden, Emin
dc.contributor.authorAri, Hatem
dc.contributor.authorKaya, Zeynettin
dc.contributor.authorTeke, Turgut
dc.date.accessioned2020-03-26T18:16:33Z
dc.date.available2020-03-26T18:16:33Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The mechanisms of the increased cardiac and vascular events in patients with OSA are not well understood. Arousal which is an important component of OSA was associated with increased sympathetic activation and electrocardiographic changes which prone to arrhythmias. We planned to examine the association among arousal, circulating Lp-PLA2 and total antioxidant capacity in male patients with OSA. Methods: Fifty male patients with newly diagnosed OSA were enrolled the study. A full-night polysomnography was performed and arousal index was obtained. Lp-PLA2 concentrations were measured in serum samples with the PLAC Test. Total antioxidant capacity in patients was determined with Antioxidant Assay Kit. Results: Arousal was positively correlated with LP-PLA2 levels (r=0.43, p=0.002) and was negatively correlated with total antioxidant capacity (r= -0.29, p=0.04). Elevated LP-PLA2 levels and decreased total antioxidant activities were found in the highest arousal quartile compared with the lowest and 2nd quartiles (p=0.02, p=0.05, respectively). LP-PLA2 was an independently predictor of arousal index in regression model (beta=0.357, p=0.002) Conclusions: This study demonstrated a moderate linear relationship between arousal and LP-PLA2 levels. Also, total antioxidant capacities were decreased in the higher arousal index. Based on the study result, the patients with higher arousal index may be prone to vascular events.en_US
dc.description.sponsorshipBilim Drug Company Ltd.en_US
dc.description.sponsorshipThe authors acknowledge to Bilim Drug Company Ltd. for the financial support for the LP-PLA2 and total antioxidant capacity assay kits. Also, the authors acknowledge to sleep laboratory staff for their contributions to the study.en_US
dc.identifier.doi10.7150/ijms.8.369en_US
dc.identifier.endpage376en_US
dc.identifier.issn1449-1907en_US
dc.identifier.issue5en_US
dc.identifier.pmid21698055en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://dx.doi.org/10.7150/ijms.8.369
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26889
dc.identifier.volume8en_US
dc.identifier.wosWOS:000292520000003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIVYSPRING INT PUBLen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectArousalen_US
dc.subjectLipoprotein-associated phospholipase A2en_US
dc.subjecttotal antioxidant statusen_US
dc.subjectcardiovascular risken_US
dc.titleThe Association Among Lipoprotein-associated Phospholipase A2 Levels, Total Antioxidant Capacity and Arousal in Male Patients with OSAen_US
dc.typeArticleen_US

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