Immune responses in women with periodontitis and preterm low birth weight: Levels of CD4+ and CD8+ T cells in gingival granulation tissue

Basit Öğe Kaydı
dc.contributor.authorKayar, Nezahat Arzu
dc.contributor.authorÇelik, İlhami
dc.contributor.authorAlptekin, Nilgün Özlem
dc.date.accessioned2020-03-26T20:20:50Z
dc.date.available2020-03-26T20:20:50Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractPreterm Low-Birth-Weight (PLBW) is frequently associated with periodontal disease. However, the mechanism is still unknown. The present study was performed to examine the possible link between periodontal infections and PLBW in post-partum women utilizing clinical parameters and CD4+ and CD8 + T lymphocytes ratio in gingival granulation tissue. Materials: The tissues used in this study consisted of 35 gingival granulation tissue biopsies from 35 mothers of healthy infants (HTBW), 35 biopsies of gingival granulation tissue from 35 mothers of PLBW within one month postpartum and gingival tissue biopsies from 7 control individual with no periodontal disease (HC). CD4+ and CD8 + T lymphocyte ratios in a unit area of the gingival granulation tissue were determined by hystometrically. Statistical analysis was performed by using Kruskal-Wallis and Mann-Whitney U tests. Results: CD8 + T lymphocytes were more prevalent in the PLBW group than in the HTBW and HC group (P < 0.05). The CD4+/CD8+ ratio in the PLBW group was lower than those of the other groups (p < 0.05). There were no statistically significant differences in CD4 + T lymphocytes counts between all groups (P > 0.05). Conclusion: Within the limits of this study it can be concluded that CD8 + T lymphocytes in gingival tissue may play important roles in the pathogenesis of periodontitis and PLBW.en_US
dc.description.sponsorship2003065en_US
dc.description.sponsorshipThis study was supported by grants from the Selcuk University Scientific Research Projects ( 2003065 ).en_US
dc.identifier.citationKayar, N. A., Çelik, İ., Alptekin, N. Ö. (2020). Immune Responses In Women With Periodontitis And Preterm Low Birth Weight: Levels Of CD4+ And CD8+ T Cells in Gingival Granulation Tissue. Archives of Oral Biology, 109.
dc.identifier.doi10.1016/j.archoralbio.2019.104551en_US
dc.identifier.issn0003-9969en_US
dc.identifier.pmid31542704en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.archoralbio.2019.104551
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38679
dc.identifier.volume109en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇelik, İlhami
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCD4+en_US
dc.subjectCD8+en_US
dc.subjectGingival granulation tissueen_US
dc.subjectLow birth weighten_US
dc.subjectPreterm birthen_US
dc.titleImmune responses in women with periodontitis and preterm low birth weight: Levels of CD4+ and CD8+ T cells in gingival granulation tissueen_US
dc.typeArticleen_US

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