Biological Subtypes and Survival Outcomes in Breast Cancer Patients with Brain Metastases (Study of the Anatolian Society of Medical Oncology)

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dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorIsikdogan, Abdurrahman
dc.contributor.authorKoca, Dogan
dc.contributor.authorKucukoner, Mehmet
dc.contributor.authorGumusay, Ozge
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorDayan, Adem
dc.date.accessioned2020-03-26T18:24:07Z
dc.date.available2020-03-26T18:24:07Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study is to determine the relationship between the survival outcomes and biological subtype in breast cancer patients with brain metastases. Methods: We retrospectively evaluated clinical data from 422 breast cancer patients with brain metastases between 2001 and 2011 from referral centers in Turkey. The study population was divided into four biological subtypes according to their hormone receptor status and HER2 expression. Results: Systemic treatment prolonged median overall survival (OS) after brain metastases in the entire group (14 vs. 3.2 months, p < 0.001). It also prolonged median OS after brain metastases in the triple negative (7.5 vs. 1.6 months, p = 0.010) and luminal A (14.3 vs. 7.1 months, p = 0.003) subgroups. The median OS for untreated patients, chemotherapy and/or hormonal therapy receiving patients, and chemotherapy and/or hormonal therapy plus targeted therapy receivers was 2, 5.8, and 17.7 months, respectively (p < 0.001), in the HER2-overexpressing subgroup. In the luminal B subgroup, it was 3.7, 5.3, and 15.4 months, respectively (p = 0.003). Conclusions: The use of systemic therapy improves OS after brain metastases in all biological subgroups. Targeted therapies also improve OS after brain metastases in HER2-positive patients. The combined use of targeted therapies and lapatinib are superior to single use and trastuzumab, respectively, in these patients. Copyright (C) 2012 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000338782en_US
dc.identifier.endpage150en_US
dc.identifier.issn0030-2414en_US
dc.identifier.issn1423-0232en_US
dc.identifier.issue3en_US
dc.identifier.pmid22814315en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000338782
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27791
dc.identifier.volume83en_US
dc.identifier.wosWOS:000307877100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBreast canceren_US
dc.subjectBrain metastasisen_US
dc.subjectBiological subtypeen_US
dc.titleBiological Subtypes and Survival Outcomes in Breast Cancer Patients with Brain Metastases (Study of the Anatolian Society of Medical Oncology)en_US
dc.typeArticleen_US

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