Does Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?

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dc.contributor.authorDalkilic, Nizamettin
dc.contributor.authorKiziltan, Erhan
dc.contributor.authorPehlivan, Ferit
dc.contributor.authorKose, Kenan
dc.date.accessioned2020-03-26T16:45:34Z
dc.date.available2020-03-26T16:45:34Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCollegenase is widely used in the process of teasing a nerve in order to perform single fiber action potential (SFAP) recordings. In this study, the effects of collagenase on nerve conduction parameters were investigated. To accomplish this, normal compound action potentials (nCAPs) were recorded from isolated frog sciatic nerve at various distances using the suction technique. Then, the same nerve was treated with collagenased Ringer's solution (3.5 mg/ml, Sigma Type XI) for 90 minutes and action potentials (cCAPs) were recorded again. Numerical analysis of these records was performed and the results were compared. Using the nCAP and cCAP recordings, the conduction velocity distributions (CVD) of the individual nerve trunks were determined by a method that we have previously described. Statistical results indicated significant differences (p<0.05) between the nCAP and cCAP CVD data. From these findings it is concluded that, when used for teasing the nerve fibers, collagenase may affect the nerve trunk conduction parameters. Specifically, a significant amount of decrease has been observed in conduction velocities of myelinated fibers having diameters smaller than 8 mum.en_US
dc.identifier.citationDalkilic, N., Kiziltan, E., Pehlivan, F., Kose, K., (2003). Does Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?. Yakugaku Zasshi-journal of the Pharmaceutical Society of Japan, 123(12), 1031-1037. DOÄ°: 10.1248/yakushi.123.1031
dc.identifier.doi10.1248/yakushi.123.1031en_US
dc.identifier.endpage1037en_US
dc.identifier.issn0031-6903en_US
dc.identifier.issue12en_US
dc.identifier.pmid14689866en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1031en_US
dc.identifier.urihttps://dx.doi.org/10.1248/yakushi.123.1031
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18417
dc.identifier.volume123en_US
dc.identifier.wosWOS:000186902800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDalkilic, Nizamettin
dc.language.isoenen_US
dc.publisherPHARMACEUTICAL SOC JAPANen_US
dc.relation.ispartofYakugaku Zasshi-journal of the Pharmaceutical Society of Japanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCompound action potentialen_US
dc.subjectCollagenaseen_US
dc.subjectFiber diameter distributionen_US
dc.subjectSuction techniqueen_US
dc.titleDoes Collagenase Affect the Electrophysiological Parameters of Nerve Trunk?en_US
dc.typeArticleen_US

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