Do microsatellite instability (MSI) and deficient mismatch repair (dMMR) affect the pathologic complete response (pCR) in patients with rectal cancer who received neoadjuvant treatment

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dc.authorid0000-0003-4261-2673
dc.authorid0000-0003-0720-3794
dc.authorid0000-0002-5084-5867
dc.authorid0000-0002-4060-7048
dc.authorid0000-0002-1614-5568
dc.authorid0000-0001-7710-0665
dc.authorid0000-0002-0096-8789
dc.authorid0000-0002-0512-1405
dc.contributor.authorAcar, Turan
dc.contributor.authorAcar, Nihan
dc.contributor.authorKamer, Erdinç
dc.contributor.authorTekindal, Mustafa Agah
dc.contributor.authorCengiz, Fevzi
dc.contributor.authorKar, Haldun
dc.contributor.authorAtahan, Kemal
dc.contributor.authorHacıyanlı, Mehmet
dc.date.accessioned2020-03-26T20:13:29Z
dc.date.available2020-03-26T20:13:29Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Zootekni ve Hayvan Besleme Bölümüen_US
dc.description.abstractRecently, individualized approaches for the treatment of locally advanced rectal cancers (RC) have been introduced to determine the most beneficial one for boosting the tumor response and assessing the response more accurately. However, despite each patient and tumor have different molecular features, the studies at the molecular level are very limited. In this study, examining the clinical factors which are predictive of pathologic complete response (pCR), helping to determine a treatment program for the management of patients with locally advanced RC, and evaluating the relation between regression grade and MMR-MSI were aimed. 341 RC cases who had undergone surgery were included and divided into three groups according to their response to neoadjuvant treatment. The following parameters were analyzed for all patients: age at diagnosis, sex, tumor location, tumor differentiation, TNM stage, histological subtype, CEA (mean: < 5 ng/ml) level, lymphovascular-neural invasion, presence of mucinous subtype, grade, MMR, and MSI statuses. 147 patients (43.2%) had no response (group 1), 141 patients (41.3%) had an intermediate response (group 2), and 53 patients (15.5%) had a complete response (group 3). Neoadjuvant chemoradiotherapy was used in all of the patients with the same protocol. Multivariate analysis revealed that clinical T stage (p: 0.099) and MMR (p: 0.048) were the parameters which were significantly associated with pCR. Since MMR and MSI statuses were found to affect pCR, more careful patient selection for "watch and wait" protocol and further studies on molecular structures of the tumors for individualized therapies are required.en_US
dc.identifier.citationAcar, T., Acar, N., Kamer, E., Tekindal, M. A., Cengiz, F., Kar, H., Atahan, K., Haciyanli, M. (2019). Do Microsatellite Instability (MSI) and Deficient Mismatch Repair (dMMR) Affect The Pathologic Complete Response (pCR) in Patients with Rectal Cancer Who Received Neoadjuvant Treatment?. Updates in Surgery, 72(1), 73-82.
dc.identifier.doi10.1007/s13304-019-00697-2en_US
dc.identifier.endpage82
dc.identifier.issn2038-131Xen_US
dc.identifier.issn2038-3312en_US
dc.identifier.pmid31863279en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage73
dc.identifier.urihttps://dx.doi.org/10.1007/s13304-019-00697-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37703
dc.identifier.wosWOS:000503797200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTekindal, Mustafa Agah
dc.language.isoenen_US
dc.publisherSPRINGER-VERLAG ITALIA SRLen_US
dc.relation.ispartofUPDATES IN SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectComplete responseen_US
dc.subjectMicrosatellite instabilityen_US
dc.subjectMismatch repairen_US
dc.subjectRectal canceren_US
dc.titleDo microsatellite instability (MSI) and deficient mismatch repair (dMMR) affect the pathologic complete response (pCR) in patients with rectal cancer who received neoadjuvant treatmenten_US
dc.typeArticleen_US

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