Interaction Between Ketoconazole and Human Serum Albumin on Epoxy Modified Magnetic Nanoparticles for Drug Delivery

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dc.contributor.authorMaltas, Esra
dc.contributor.authorOzmen, Mustafa
dc.contributor.authorYildirimer, Burak
dc.contributor.authorKucukkolbasi, Semahat
dc.contributor.authorYildiz, Salih
dc.date.accessioned2020-03-26T18:42:12Z
dc.date.available2020-03-26T18:42:12Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) were modified with [3-(2,3-epoxypropoxy)propyl] trimethoxy silane, which resulted in formation of epoxy groups on the particles surface. The epoxy functionalized SPIONs can bind to human serum albumin (HSA). The binding amount of HSA to epoxy modified SPIONs was found to be as 32.7 mu M for 1 mg epoxy modified SPIONs at 280 and 342 nm of excitation and emission wavelengths by using fluorescence spectroscopy. Interaction of ketoconazole with HSA immobilized epoxy functionalized SPIONs was studied at 300 and 390 nm of excitation and emission wavelengths, respectively. Binding mechanism of ketoconazole and HSA was identified by Stern-Volmer equation. Thermodynamic parameters (Delta H, Delta S and Delta G) were also estimated for the interaction. Therefore, the nature of the binding forces was found to be as hydrophobic interaction. Protein and drug attachments were also examined by Infrared spectroscopy (IR) and Scanning Electron Microscopy (SEM). This study show that prepared albumin-based magnetic nanoparticles carrier systems represents an attractive strategy for drug delivery.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipWe would like to thank The Research Foundation of Selcuk University (BAP) for financial support of this work.en_US
dc.identifier.doi10.1166/jnn.2013.7742en_US
dc.identifier.endpage6528en_US
dc.identifier.issn1533-4880en_US
dc.identifier.issn1533-4899en_US
dc.identifier.issue10en_US
dc.identifier.pmid24245109en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6522en_US
dc.identifier.urihttps://dx.doi.org/10.1166/jnn.2013.7742
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29575
dc.identifier.volume13en_US
dc.identifier.wosWOS:000328704000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER SCIENTIFIC PUBLISHERSen_US
dc.relation.ispartofJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMagnetic Nanoparticlesen_US
dc.subjectSilanizationen_US
dc.subjectHuman Serum Albuminen_US
dc.subjectKetoconazoleen_US
dc.subjectFluorescence Spectroscopyen_US
dc.titleInteraction Between Ketoconazole and Human Serum Albumin on Epoxy Modified Magnetic Nanoparticles for Drug Deliveryen_US
dc.typeArticleen_US

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