A comparative assessment of biological effects and chemical profile of Italian asphodeline lutea extracts

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dc.authorid0000-0002-0840-825X
dc.authorid0000-0002-8698-9440
dc.authorid0000-0001-5870-7509
dc.authorid0000-0001-6548-7823
dc.authorid0000-0002-7346-7395
dc.authorid0000-0003-3962-8666
dc.contributor.authorMelucci, Dora
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorLocatelli, Clinio
dc.contributor.authorZappi, Alessandro
dc.contributor.authorDe laurentiis, Francesco
dc.contributor.authorCarradori, Simone
dc.contributor.authorCampestre, Cristina
dc.contributor.authorLeporini, Lidia
dc.contributor.authorZengin, Gökhan
dc.contributor.authorPicot, Carene Marie Nancy
dc.contributor.authorMenghini, Luigi
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:52:40Z
dc.date.available2020-03-26T19:52:40Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA. Zinc, cadmium, lead, and copper contents were also determined. All the samples inhibited acetylcholinesterase (from 1.51 to 2.20 mg GALAEs/g extract), tyrosinase (from 7.50 to 25.3 mg KAEs/g extract), and alpha-amylase (from 0.37 to 0.51 mmol ACAEs/g extract). Aloe-emodin and physcion were present in all parts, while rhein was not detected. The phenolic profile and the heavy metals composition of specimens gathered from three different regions of Italy were different. It can be argued that samples collected near the street can contain higher concentrations of heavy metals. The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance.en_US
dc.description.sponsorshipItalian Ministry of University (FAR)en_US
dc.description.sponsorshipThis work was supported by grants from the Italian Ministry of University (FAR 2016). The research is part of the project "Filiera delle piante officinali in Abruzzo".en_US
dc.identifier.citationMelucci, D., Locatelli, M., Locatelli, C., Zappi, A., Laurentiis, F. D., Carradori, S., Campestre, C., Leporini, L., Zengin, G., Picot, C. M. N., Menghini, L., Mahomoodally, M. F. (2018). A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts. Molecules, 23(2), 1-14.
dc.identifier.doi10.3390/molecules23020461en_US
dc.identifier.endpage14
dc.identifier.issn1420-3049en_US
dc.identifier.issue2en_US
dc.identifier.pmid29463056en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1
dc.identifier.urihttps://dx.doi.org/10.3390/molecules23020461
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36233
dc.identifier.volume23en_US
dc.identifier.wosWOS:000426436300241en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsphodeline luteaen_US
dc.subjectHPLC-PDAen_US
dc.subjectHeavy metalsen_US
dc.subjectTyrosinaseen_US
dc.subjectDiabetesen_US
dc.subjectNeurodegenerative diseaseen_US
dc.titleA comparative assessment of biological effects and chemical profile of Italian asphodeline lutea extractsen_US
dc.typeArticleen_US

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