Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study

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dc.contributor.authorApiliogullari, S.
dc.contributor.authorKeles, B.
dc.contributor.authorApiliogullari, B.
dc.contributor.authorBalasar, M.
dc.contributor.authorYilmaz, H.
dc.contributor.authorDuman, A.
dc.date.accessioned2020-03-26T17:17:07Z
dc.date.available2020-03-26T17:17:07Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective: Pain on injection is still a problem with propofol. The purpose of the study was to compare the effectiveness of diphenhydramine and lidocaine on pain caused by propofol at the site of injection. Methods: One hundred and eighty ASA I-II adults undergoing elective surgery were randomly assigned into three groups of 60 each. Group I (placebo) received 2 mL normal saline, Group 11 received 2 mL (40 mg) 2% lidocaine and Group III received 2 mL (20 mg) diphenhydramine intravenously (i.v.) during a 1-min venous occlusion, followed by propofol into a cephalic forearm vein of the antecubital fossa. Pain assessment was made immediately after propofol injection. Results: In the placebo group 25 (41.7%) patients experienced pain during propofol injection as compared to 2 (3.3%) and 3 (5.0%) in the lidocaine and diphenhydramine groups, respectively. The prevalence of pain and pain score were significantly less in both the lidocaine and diphenhydramine groups than in the placebo group (P = 0.00). No difference was found between the diphenhydramine and lidocaine groups (P = 0.60). Conclusion: Previous injection of diphenhydramine with venous occlusion can be considered as an alternative to lidocaine for reducing the prevalence of pain caused by injection of propofol into peripheral veins.en_US
dc.identifier.doi10.1017/S026502150600202Xen_US
dc.identifier.endpage238en_US
dc.identifier.issn0265-0215en_US
dc.identifier.issue3en_US
dc.identifier.pmid17202008en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S026502150600202X
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21275
dc.identifier.volume24en_US
dc.identifier.wosWOS:000245129300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF ANAESTHESIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpropofolen_US
dc.subjectlidocaineen_US
dc.subjectdiphenhydramineen_US
dc.subjectinjections intravenous, adverse effects, painen_US
dc.titleComparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized studyen_US
dc.typeArticleen_US

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