Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats

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dc.contributor.authorUysal, N
dc.contributor.authorOzdemir, D
dc.contributor.authorDayi, A
dc.contributor.authorYalaz, G
dc.contributor.authorBaltaci, AK
dc.contributor.authorBediz, CS
dc.date.accessioned2020-03-26T16:57:04Z
dc.date.available2020-03-26T16:57:04Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVES: It is known that maternal deprivation (MD) may alter cognitive functions such as learning and memory in adult life by effecting normal growth and development. However, the mechanisms of these cognitive alterations are unknown. The aim of this study is to investigate the effects of maternal deprivation on cognition and melatonin production in adolescent male and female rats. METHODS: The litters were separated daily from their mothers for 6 hours on postnatal days 2 to 20. The spatial memory performance was evaluated using a Morris water maze between the postnatal 26th and 32nd days. Plasma melatonin levels were determined on postnatal days 42. RESULTS: MD-rats had longer escape latencies at the second, third and fifth days of training days and spend significantly less time in probe trial, compared to control animals. MAIN FINDINGS: The repeated maternal deprivation caused low blood melatonin levels and there was a significant negative correlation between blood melatonin levels and spatial memory performance in both of male and female adolescent rats. CONCLUSION: These results suggest an association between melatonin production and neurodevelopment. Further studies are needed to determine the interaction between maternal deprivation and pineal gland maturation/function.en_US
dc.identifier.endpage560en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue5en_US
dc.identifier.pmid16264401en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage555en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19709
dc.identifier.volume26en_US
dc.identifier.wosWOS:000234612300021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMAGHIRA & MAAS PUBLICATIONSen_US
dc.relation.ispartofNEUROENDOCRINOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmaternal deprivationen_US
dc.subjectspatial memoryen_US
dc.subjectwater mazeen_US
dc.subjectmelatoninen_US
dc.subjectbrainen_US
dc.titleEffects of maternal deprivation on melatonin production and cognition in adolescent male and female ratsen_US
dc.typeArticleen_US

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