The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode

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dc.contributor.authorSelek, Salih
dc.contributor.authorSavas, Haluk A.
dc.contributor.authorGergerlioglu, H. Serdar
dc.contributor.authorBulbul, Feridun
dc.contributor.authorUz, Efkan
dc.contributor.authorYumru, Mehmet
dc.date.accessioned2020-03-26T17:28:00Z
dc.date.available2020-03-26T17:28:00Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and aims: Studies have already pointed out a possible pathophysiological role of oxidative and antioxidative molecules in bipolar disorder. We aimed to evaluate the activity and levels of antioxidant superoxide dismutase (SOD), and oxidant nitric oxide (NO), in bipolar I depressive episode (BD-DE) patients in a prospective design. Method: 30 BD-DE patients, diagnosed according to DSM IV, and 30 healthy volunteer controls were included. The serum levels of NO and SOD have been studied when admitted to hospital (1st) and on the 30th days. Clinical outcome was measured by Hamilton Depression Scale (HAM-D). The patients were allowed to have their treatments. One patient was dropped out due to insufficient sampling. Results: As in the previous studies, NO 1st day levels were significantly higher in patients and SOD 1st day activity was significantly low (p < 0.0 1). NO levels significantly decreased (p < 0.0 1) and normalized, as SOD activity significantly increased but did not reach to the controls' levels (p < 0.01) on the 30th day. Conclusion: Despite normalized NO levels, persistent low SOD activity might point out an oxidative imbalance in BD-DE. Chronic low SOD activity may be associated with incapacity of coping with oxidative stress. This research connotes the probable oxidative imbalance in BD-DE and discusses that phenomenon within the continuum of the disease state. (C) 2007 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jad.2007.08.006en_US
dc.identifier.endpage94en_US
dc.identifier.issn0165-0327en_US
dc.identifier.issn1573-2517en_US
dc.identifier.issue01.03.2020en_US
dc.identifier.pmid17869345en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jad.2007.08.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22692
dc.identifier.volume107en_US
dc.identifier.wosWOS:000254546000010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofJOURNAL OF AFFECTIVE DISORDERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectnitric oxideen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectbipolar disorderen_US
dc.subjectdepressionen_US
dc.subjectoxidative stressen_US
dc.titleThe course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episodeen_US
dc.typeArticleen_US

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