In vivo laser confocal microscopic findings in patients with epithelial basement membrane dystrophy

dc.contributor.authorBozkurt, Banu
dc.contributor.authorIrkec, Murat
dc.date.accessioned2020-03-26T17:38:56Z
dc.date.available2020-03-26T17:38:56Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPURPOSE. To evaluate the corneal characteristics of patients with epithelial basement membrane dystrophy (EBMD) using an in vivo laser confocal microscope, Heidelberg Retina Tomograph II, Rostock Cornea Module (HRT II RCM). METHODS. Sixteen women and 13 men who were diagnosed with or suspected to have EBMD were included in the study. The mean age of the patients was 56.4 +/- 17.2 years within a range of 25 to 81 years. Nine patients (31%) had a history of recurrent corneal erosions and 3 patients had been misdiagnosed with herpetic epithelial keratitis. The remaining 17 patients were asymptomatic and EBMD was diagnosed incidentally during routine eye examinations. RESULTS. Confocal microscopy revealed highly reflective tissue in various configurations within the intermediate and basal epithelial cell layers corresponding to the abnormal basement membrane extending into the epithelium. There were thin, parallel hyperreflective lines and high contrast round lesions in sizes ranging between 10 and 250 mu m within the epithelium. Basal epithelial cells around the abnormal basement membrane and cysts seemed to be highly distorted. In two subjects with bleb-like disorder, the authors observed circular or oval hyporeflective areas with a diameter ranging between 40 and 100 mu m at the level of basal epithelium and the Bowman layer, accompanied by hyperreflective, linear structures extending into the epithelium. CONCLUSIONS. EBMD is most commonly asymptomatic and undiagnosed; however, it might be associated with recurrent corneal erosions and lead to severe complications after LASIK surgery. The confocal images are highly characteristic for EBMD; therefore, confocal microscopy seems to be a valuable tool in the diagnosis of EBMD. (Eur J Ophthalmol 2009; 19: 348-54)en_US
dc.identifier.endpage354en_US
dc.identifier.issn1120-6721en_US
dc.identifier.issn1724-6016en_US
dc.identifier.issue3en_US
dc.identifier.pmid19396777en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage348en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23610
dc.identifier.volume19en_US
dc.identifier.wosWOS:000265788700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OPHTHALMOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEpithelial basement membrane dystrophyen_US
dc.subjectBleb-like dystrophyen_US
dc.subjectHRT II RCMen_US
dc.subjectIn vivo confocal microscopyen_US
dc.titleIn vivo laser confocal microscopic findings in patients with epithelial basement membrane dystrophyen_US
dc.typeArticleen_US

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