Micronucleus frequency in acquired middle ear cholesteatoma

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dc.contributor.authorÖztürk, Kayhan
dc.contributor.authorYıldırım, M. Selman
dc.contributor.authorAcar, Hasan
dc.contributor.authorArıkoğlu, Hilal
dc.contributor.authorArbağ, Hamdi
dc.contributor.authorÖzer, Bedri
dc.date.accessioned2020-03-26T16:55:21Z
dc.date.available2020-03-26T16:55:21Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective - To determine the micronucleus (MN) frequency of acquired cholesteatoma tissue using an MN assay. Material and Methods - Eighteen patients were diagnosed as having chronic otitis media with acquired cholesteatoma and were divided into primary and secondary acquired cholesteatoma groups. Cholesteatoma tissue and normal tissue specimens from the external ear canal skin were taken from the patients during surgical operations. MN frequencies of cholesteatoma and control samples were determined according to standard criteria. Results - The MN frequencies of the cholesteatoma and control tissues were 0.54% +/- 0.31% and 0.24% +/- 0.11%, respectively (p< 0.01). MN frequencies for the primary and secondary acquired cholesteatoma groups were 0.63% +/- 0.36% and 0.46% +/- 0.26%, respectively ( p > 0.05). MN frequencies in cholesteatoma patients without and with complications were 0.42% +/- 0.19% and 0.85% +/- 0.37%, respectively ( p< 0.05). Conclusion - MN frequencies were found to be increased in cholesteatoma tissues when compared with external ear canal skin. The MN frequency in five cases with complications was higher than in cases without complications. These results indicate that there could be associations between MN frequency and acquired cholesteatoma and between MN frequency and complications.en_US
dc.identifier.doi10.1080/00016480310016857en_US
dc.identifier.endpage928en_US
dc.identifier.issn0001-6489en_US
dc.identifier.issn1651-2251en_US
dc.identifier.issue8en_US
dc.identifier.pmid15513528en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage924en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00016480310016857
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19127
dc.identifier.volume124en_US
dc.identifier.wosWOS:000223998000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofACTA OTO-LARYNGOLOGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCholesteatomaen_US
dc.subjectComplicationsen_US
dc.subjectMicronucleus assayen_US
dc.titleMicronucleus frequency in acquired middle ear cholesteatomaen_US
dc.typeArticleen_US

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