Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

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dc.contributor.authorCengiz, Nureddin
dc.contributor.authorKavak, Servet
dc.contributor.authorGuzel, Ali
dc.contributor.authorOzbek, Hanefi
dc.contributor.authorBektas, Hava
dc.contributor.authorHim, Aydin
dc.contributor.authorErdogan, Ender
dc.date.accessioned2020-03-26T18:42:16Z
dc.date.available2020-03-26T18:42:16Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMore than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl4). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl4-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl4. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl4 group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from the CCl4 group. Sesame did not show a hepatoprotective effect in CCl4-induced liver toxicity.en_US
dc.identifier.doi10.1007/s00232-012-9494-7en_US
dc.identifier.endpage6en_US
dc.identifier.issn0022-2631en_US
dc.identifier.issn1432-1424en_US
dc.identifier.issue1en_US
dc.identifier.pmid22915054en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00232-012-9494-7
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29593
dc.identifier.volume246en_US
dc.identifier.wosWOS:000313202400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF MEMBRANE BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectHistologyen_US
dc.subjectLiveren_US
dc.subjectRaten_US
dc.subjectSesameen_US
dc.subjectSesamum indicum L.en_US
dc.subjectALTen_US
dc.subjectASTen_US
dc.subjectALPen_US
dc.titleInvestigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicityen_US
dc.typeArticleen_US

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