High-sensitivity C-reactive protein, lipoprotein-related phospholipase A(2), and acute ischemic stroke

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dc.contributor.authorKara, Hasan
dc.contributor.authorAkinci, Murat
dc.contributor.authorDegirmenci, Selim
dc.contributor.authorBayir, Aysegul
dc.contributor.authorAk, Ahmet
dc.contributor.authorNayman, Alaaddin
dc.contributor.authorUnlu, Ali
dc.date.accessioned2020-03-26T18:50:58Z
dc.date.available2020-03-26T18:50:58Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Serum biomarkers may be useful for early diagnosis of acute ischemic stroke, exclusion of other diseases that may mimic stroke, and prediction of infarct volume. We evaluated serum high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-related phospholipase A(2) (Lp-PLA2) in patients who had acute ischemic stroke. Methods: In 200 patients who presented to an emergency service (acute ischemic stroke, 102 patients; control with no stroke, 98 patients), stroke patients were evaluated with the Canadian neurological scale and diffusion-weighted magnetic resonance imaging, and all patients were evaluated with the Glasgow coma scale and their serum hs-CRP level and Lp-PLA2 activity were assessed. The volume of stroke lesions was calculated from magnetic resonance images. Results: Patients who had stroke had higher mean serum hs-CRP level (stroke, 7 +/- 6 mg/dL; control, mean +/- standard deviation 1 +/- 1 mg/dL; P <= 0.001) and Lp-PLA2 activity (stroke, mean +/- standard deviation 113 +/- 86 nmol/min/mL; control, mean +/- standard deviation 103 +/- 50 nmol/min/mL; P <= 0.001) than control patients who did not have stroke. The mean hs-CRP level and Lp-PLA2 activity were higher in patients who had greater stroke severity (lower Canadian neurological scale score) and were higher in patients who had larger volume strokes. Conclusion: Higher hs-CRP level and Lp-PLA2 activity are significantly associated with more severe neurologic impairment and larger infarct size in patients who have acute ischemic stroke. These biomarkers may be useful for rapid diagnosis and prediction of ischemic tissue volume in the early stage of ischemic stroke. These findings may be important for health care facilities that have limited access to emergency computed tomography scanning for the diagnosis of stroke.en_US
dc.description.sponsorshipSelcuk Universitesi Bilimsel Arastirma Projeleri KoordinatorluguSelcuk Universityen_US
dc.description.sponsorshipThis study was supported by Selcuk Universitesi Bilimsel Arastirma Projeleri Koordinatorlugu.en_US
dc.identifier.doi10.2147/NDT.S67665en_US
dc.identifier.endpage1457en_US
dc.identifier.issn1178-2021en_US
dc.identifier.pmid25125979en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1451en_US
dc.identifier.urihttps://dx.doi.org/10.2147/NDT.S67665
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30903
dc.identifier.volume10en_US
dc.identifier.wosWOS:000339926600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDOVE MEDICAL PRESS LTDen_US
dc.relation.ispartofNEUROPSYCHIATRIC DISEASE AND TREATMENTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcerebrovascular accidenten_US
dc.subjectatherosclerosisen_US
dc.subjectinflammationen_US
dc.subjectbiomarkeren_US
dc.titleHigh-sensitivity C-reactive protein, lipoprotein-related phospholipase A(2), and acute ischemic strokeen_US
dc.typeArticleen_US

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