Zinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brain

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dc.contributor.authorBediz, CS
dc.contributor.authorBaltaci, AK
dc.contributor.authorMogulkoc, R
dc.contributor.authorOztekin, E
dc.date.accessioned2020-03-26T17:04:47Z
dc.date.available2020-03-26T17:04:47Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractExtremely low-frequency (0-300 Hz) electromagnetic fields (EMFs) generated by power lines, wiring and home appliances are ubiquitous in Our environment. All populations are now exposed to EMF, and exposure to EMF may pose health risks. Some of the adverse health effects of EMF exposure are lipid peroxidation and cell damage in various tissues. This study has investigated the effects of EMF exposure and zinc administration on lipid peroxidation in the rat brain. Twenty-four male Sprague-Dawley rats were randomly allocated to three groups; they were maintained untreated for 6 months (control, n=8), exposed to low-frequency (50 Hz) EMF for 5 minutes every other day for 6 months (n=8), or exposed to EMF and received Zinc sulfate daily (3 mg/kg/day) intraperitoneally (n=8). We measured plasma levels of zinc and thiobarbituric acid reactive substances (TBARS), and levels of reduced glutathione (GSH) in erythrocytes. TBARS and GSH levels were also determined in the brain tissues. TBARS levels in the plasma and brain tissues were higher in EMF-exposed rats with or without zinc supplementation, than those in controls (p<0.001). In addition, TBARS levels were significantly lower in the zinc-supplemented rats than those in the EMF-exposed rats (p<0.001). GSH levels were significantly decreased in the brain and erythrocytes of the EMF-exposed rats (p<0.01), and were highest in the zinc-supplemented rats (p<0.001). Plasma zinc was significantly lower in the EMF-exposed rats than those in controls (p<0.001), while it was hi-hest in the zinc-supplemented rats (p<0.001). The present study suggests that long-term exposure to low-frequency EMF increases lipid peroxidation in the brain, which may be ameliorated by Zinc Supplementation.en_US
dc.identifier.doi10.1620/tjem.208.133en_US
dc.identifier.endpage140en_US
dc.identifier.issn0040-8727en_US
dc.identifier.issn1349-3329en_US
dc.identifier.issue2en_US
dc.identifier.pmid16434836en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://dx.doi.org/10.1620/tjem.208.133
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20771
dc.identifier.volume208en_US
dc.identifier.wosWOS:000234781900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTOHOKU UNIV MEDICAL PRESSen_US
dc.relation.ispartofTOHOKU JOURNAL OF EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectelectromagnetic fielden_US
dc.subjectlipid peroxidationen_US
dc.subjectzincen_US
dc.subjectbrainen_US
dc.titleZinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brainen_US
dc.typeArticleen_US

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