Effect of postmenopausal hormone replacement therapy on cardiovascular performance

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dc.contributor.authorÖzdemir, Kurtuluş
dc.contributor.authorÇelik, Çetin
dc.contributor.authorAltunkeser, Bülent Behlül
dc.contributor.authorİçli, Abdullah
dc.contributor.authorAlbeni, Havva
dc.contributor.authorDüzenli, Mehmet Akif
dc.contributor.authorAkyürek, Cemalettin
dc.contributor.authorGök, Hasan
dc.date.accessioned2020-03-26T16:48:20Z
dc.date.available2020-03-26T16:48:20Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractSumm.: Postmenopausal hormone replacement therapy (HRT) has usually been evaluated the relationship with atherosclerotic disease, whereas its effect on direct cardiac functions hasn't been investigated in detail. This study was planned to investigate the long-term effects of HRT on cardiac functions and exercise performance. Methods: Thirty-six postmenopausal women (mean age: 51+/-4 years, 39-60 years) were prospectively analyzed with pulsed wave Doppler echocardiography and symptom-limited exercise stress test before HRT (oral 0.625 mg conjugated estrogen and 2.5 mg medroxyprogesteron acetate/day), and at the third and the sixth months. The effect of HRT on left ventricular ejection fraction (EF), early filling velocity (E wave) and late filling velocity (A wave), E wave deceleration time (EDT), E/A ratio, myocardial performance index (MPI), exercise duration and METS changes were examined. Results: HRT did not significantly alter the left ventricular EF. At the third month of HRT, there was an insignificant increase in E wave, EDT, and E/A ratio, whereas an insignificant decrease was noted in MPI (P > 0.05). However, at the sixth month of HRT, these changes became significant (68+/-12 vs. 75+/-13 cm/s, P < 0.01; 171+/-24 vs. 184+/-14 ms, P < 0.01; 1.01+/-0.23 vs. 1.11+/-0.27, P < 0.01, and 44+/-9 vs. 39+/-8%, P < 0.001, respectively). On the other hand, exercise duration and exercise METS values showed significant improvements at the third month of HRT (423 104 vs. 482+/-104 s, P < 0.001; 8.2+/-1.7 vs. 9.1+/-2 METS, P < 0.001). These improvements also continued at the sixth month of HRT. In conclusion, postmenopausal HRT leads to a progressive improvement on left ventricular function parameters, and in parallel, in exercise performance. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0378-5122(03)00248-2en_US
dc.identifier.endpage113en_US
dc.identifier.issn0378-5122en_US
dc.identifier.issn1873-4111en_US
dc.identifier.issue2en_US
dc.identifier.pmid14757269en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0378-5122(03)00248-2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19019
dc.identifier.volume47en_US
dc.identifier.wosWOS:000188960700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofMATURITASen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthormone replacement therapyen_US
dc.subjectechocardiographyen_US
dc.subjectexercise testen_US
dc.subjectmenopauseen_US
dc.titleEffect of postmenopausal hormone replacement therapy on cardiovascular performanceen_US
dc.typeArticleen_US

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