Coenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic rats

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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorPehlivan, Sultan
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorIskit, Alper Bektas
dc.date.accessioned2020-03-26T19:34:22Z
dc.date.available2020-03-26T19:34:22Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Coenzyme Q10 (CoQ10) is a naturally occurring, lipid-soluble antioxidant and an essential electron carrier in the mitochondrial respiratory chain. In sepsis, CoQ10 deficiency induced by mitochondrial failure can lead to hypoxia, hypoperfusion, oxidative organ damage and finally death. We aimed to investigate the effects of CoQ10 on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Methods: Wistar rats were divided into Sham, CLP, Sham + CoQ10, CLP + CoQ10 subgroups. CoQ10 (10 mg/kg/day) or vehicle (olive oil; 1 mL/kg/day) was intraperitoneally injected for 15 days. At 16th day, Sham or CLP operation was performed. 20 h after the operations, MABF and phenylephrine responses of isolated aortic rings were measured. Tissue samples were obtained for histopathological and biochemical evaluations. Furthermore, survival rates were monitored throughout 96 h. Results: CoQ10 prevented mesenteric hypoperfusion and aortic dysfunction induced by CLP. Survival rate was % 0 at 46th h in CLP group, but in CLP + CoQ10 group it was 37.5% at the end of 96 h. CLP-induced elevations of serum AST, ALT, LDH, BUN, Cr and inflammatory cytokine (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) levels were blocked by CoQ10. CoQ10 restored the increased liver, lung, spleen and kidney malondialdehyde levels and as well as reduced liver and spleen glutathione levels. The protective effects of CoQ10 on multiple organ damage were also observed histopathologically. Conclusions: CoQ10 showed protective effects in sepsis due to its preservative effects on mesenteric perfusion, aortic function and also its anti-inflammatory and antioxidative effects. (C) 2017 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research CoordinationSelcuk University [15401079]en_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Research Coordination (No: 15401079).en_US
dc.identifier.doi10.1016/j.biopha.2017.05.017en_US
dc.identifier.endpage919en_US
dc.identifier.issn0753-3322en_US
dc.identifier.issn1950-6007en_US
dc.identifier.pmid28501779en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage912en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2017.05.017
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34886
dc.identifier.volume91en_US
dc.identifier.wosWOS:000406399900101en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofBIOMEDICINE & PHARMACOTHERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoenzyme Q10en_US
dc.subjectSepsisen_US
dc.subjectSurvivalen_US
dc.subjectMultiple organ damageen_US
dc.subjectVascular hyporeactivityen_US
dc.subjectMesenteric arterial blood flowen_US
dc.titleCoenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic ratsen_US
dc.typeArticleen_US

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